Abnormalities in cortical gray matter density in borderline personality disorder

R. Rossi, M. Lanfredi, M. Pievani, M. Boccardi, P. E. Rasser, P. M. Thompson, E. Cavedo, M. Cotelli, S. Rosini, R. Beneduce, S. Bignotti, L. R. Magni, L. Rillosi, S. Magnaldi, M. Cobelli, G. Rossi, G. B. Frisoni

Research output: Contribution to journalArticle


Background: Borderline personality disorder (BPD) is a chronic condition with a strong impact on patients' affective, cognitive and social functioning. Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease. We aimed to investigate gray matter alterations over the whole cortex in a group of Borderline Personality Disorder (BPD) patients compared to healthy controls (HC). Methods: Magnetic resonance-based cortical pattern matching was used to assess cortical gray matter density (GMD) in 26 BPD patients and in their age- and sex-matched HC (age: 38. ±. 11; females: 16, 61%). Results: BPD patients showed widespread lower cortical GMD compared to HC (4% difference) with peaks of lower density located in the dorsal frontal cortex, in the orbitofrontal cortex, the anterior and posterior cingulate, the right parietal lobe, the temporal lobe (medial temporal cortex and fusiform gyrus) and in the visual cortex ( P

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalEuropean Psychiatry
Issue number2
Publication statusPublished - Feb 1 2015


  • Borderline personality disorder
  • MRI
  • Neuroimaging

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Rossi, R., Lanfredi, M., Pievani, M., Boccardi, M., Rasser, P. E., Thompson, P. M., Cavedo, E., Cotelli, M., Rosini, S., Beneduce, R., Bignotti, S., Magni, L. R., Rillosi, L., Magnaldi, S., Cobelli, M., Rossi, G., & Frisoni, G. B. (2015). Abnormalities in cortical gray matter density in borderline personality disorder. European Psychiatry, 30(2), 221-227. https://doi.org/10.1016/j.eurpsy.2014.11.009