Serum lipoprotein composition was examined in 18 male patients (mean age 44 ± 0.9 years) who had undergone coronary artery by-pass surgery because of premature coronary heart disease (PCHD) and in 18 control subjects, matched with patients for sex, age, body mass index and serum cholesterol and triglyceride. Cholesterol, triglyceride and apolipoprotein B (apo B) concentrations in very low density lipoprotein (VLDL) and in low density lipoprotein (LDL) did not differ in two groups, but high density lipoprotein (HDL)-cholesterol was significantly lower in PCHD patients (P <0.02). Cholesterol/apo B, triglyceride/apo B and phospholipid/apo B ratios in VLDL were significantly higher in patients than in controls (P <0.05, P <0.01 and P <0.001, respectively). The relative VLDL enrichment in cholesterol was mainly due to the non-esterified moiety (P <0.01). These VLDL abnormalities as well as the low HDL-cholesterol suggest an impairment of VLDL catabolism in PCHD patients.
- Apolipoprotein B
- Lipoprotein composition
- Premature coronary heart disease
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine