Abnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer disease

Alessandro Padovani, Barbara Borroni, Francesca Colciaghi, Carla Pettenati, Elisabetta Cottini, Chiara Agosti, Gian Luigi Lenzi, Carlo Caltagirone, Marco Trabucchi, Flaminio Cattabeni, Monica Di Luca

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Patients affected by sporadic Alzheimer disease (AD) show a significant alteration of amyloid precursor protein (APP) forms in platelets when compared with patients with dementia but without AD and age-matched controls. Objective: To evaluate the ratio of platelet APP forms (APPr) in early-stage AD and mild cognitive impairment (MCI) and its potential as a biomarker for the early identification of AD. Setting: Community population-based sample of patients admitted to 4 AD centers for investigation of cognitive disturbances. Design and Methods: Thirty-five patients with mild AD (mAD), 21 patients with very mild AD (vmAD), 30 subjects with MCI, and 25 age-matched controls were included. The APPr was evaluated by Western blot analysis in platelet homogenate. Results: Compared with controls (mean ±SD, 0.93±0.3), the mean APPr was decreased in patients with mAD (0.44±0.24; P

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalArchives of Neurology
Volume59
Issue number1
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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