Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder

J. Perez, R. Zanardi, S. Mori, M. Gasperini, E. Smeraldi, G. Racagni

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the study was to assess cAMP-dependent endogenous phosphorylation in platelets from euthymic bipolar patients. Methods: Platelets from 10 drug-free euthymic patients with bipolar disorder were compared with those from 10 age- and sex-matched healthy subjects. Basal and cAMP-stimulated protein phosphorylation was examined in each group. Results: Endogenous phosphorylation in both the healthy volunteers and the bipolar patients was significantly stimulated by cAMP; the major polypeptides had apparent molecular weights of 38 and 22 kDa. The cAMP-stimulated 32P incorporation differed between the bipolar patients and the comparison subjects only in the 22-kDa band. Conclusions: These data suggest a possible role of cAMP-dependent protein phosphorylation in the pathophysiology of bipolar disorder.

Original languageEnglish
Pages (from-to)1204-1206
Number of pages3
JournalAmerican Journal of Psychiatry
Volume152
Issue number8
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Perez, J., Zanardi, R., Mori, S., Gasperini, M., Smeraldi, E., & Racagni, G. (1995). Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder. American Journal of Psychiatry, 152(8), 1204-1206.