Abnormalities of chromosome 7q and Tac expression in T cell leukemias

V Brito-Babapulle, E Matutes, L Parreira, D Catovsky

Research output: Contribution to journalArticlepeer-review

Abstract

Clonal chromosome abnormalities were demonstrated in 13 cases of T cell leukemia with a mature membrane phenotype. The cases comprised two adult T cell lymphoma leukemia (ATLL), five Sézary syndrome (SS), three T prolymphocytic leukemia (T-PLL), and three T chronic lymphocytic leukemia (T-CLL). The presence of clonal chromosome abnormalities in the three cases of T-CLL supports the view that although clinically benign, this disorder probably represents a neoplastic process. Cells from six of 11 patients were tested and found to be reactive with monoclonal antibody (McAb) anti-Tac in the absence of mitogens (two ATLL, two SS, and two T-PLL). Only the two ATLL patients were serologically positive for the human T cell leukemia virus I (HTLV-I), and their cells showed a higher anti-Tac reactivity. Chromosome 7 abnormalities were observed in seven cases (two ATLL, three SS, two T-PLL), and a strong correlation was seen between the presence of a 7q abnormality and the expression of the Tac antigen (T cell growth factor receptor). These findings are discussed in relation to the localization of T cell receptor genes on chromosome 7 and possible mechanisms for the activation of the Tac gene.

Original languageEnglish
Pages (from-to)516-21
Number of pages6
JournalBlood
Volume67
Issue number2
Publication statusPublished - Feb 1986
Externally publishedYes

Keywords

  • Antibodies, Monoclonal
  • Chromosome Aberrations/genetics
  • Chromosome Banding
  • Chromosome Disorders
  • Chromosomes, Human, 6-12 and X
  • Humans
  • Leukemia/genetics
  • Receptors, Immunologic/genetics
  • Receptors, Interleukin-2
  • T-Lymphocytes/immunology

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