Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

C. Babiloni, C. Del Percio, R. Lizio, G. Noce, S. Cordone, S. Lopez, A. Soricelli, R. Ferri, M.T. Pascarelli, F. Nobili, D. Arnaldi, D. Aarsland, F. Orzi, C. Buttinelli, F. Giubilei, M. Onofrj, F. Stocchi, P. Stirpe, P. Fuhr, U. Gschwandtner & 17 others G. Ransmayr, G. Caravias, H. Garn, F. Sorpresi, M. Pievani, G.B. Frisoni, F. D'Antonio, C. De Lena, B. Güntekin, L. Hanoğlu, E. Başar, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, R. Franciotti, M.F. De Pandis, L. Bonanni

Research output: Contribution to journalArticle

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Abstract

The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini–Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85–0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery. © 2017 Elsevier Inc.
Original languageEnglish
Pages (from-to)143-158
Number of pages16
JournalNeurobiology of Aging
Volume55
DOIs
Publication statusPublished - 2017

Fingerprint

Cortical Synchronization
Lewy Body Disease
Dementia
Electroencephalography
Alzheimer Disease
Parkinson Disease
Arousal
Brain
Wakefulness
Validation Studies
Electromagnetic Phenomena

Keywords

  • Alzheimer's disease dementia (ADD)
  • Dementia with Lewy body (DLB)
  • Exact low-resolution brain electromagnetic source tomography (eLORETA)
  • Parkinson's disease dementia (PDD)
  • Resting state electroencephalographic (rsEEG) rhythms
  • aged
  • alpha rhythm
  • Alzheimer disease
  • arousal
  • Article
  • beta rhythm
  • controlled study
  • cortical synchronization
  • delta rhythm
  • diffuse Lewy body disease
  • educational status
  • electroencephalogram
  • exploratory research
  • female
  • human
  • major clinical study
  • male
  • measurement accuracy
  • Mini Mental State Examination
  • occipital lobe
  • Parkinson disease
  • priority journal
  • receiver operating characteristic
  • retrospective study
  • sensitivity and specificity
  • theta rhythm
  • wakefulness
  • brain cortex
  • electroencephalography
  • pathophysiology
  • physiology
  • rest
  • visual system function
  • Aged
  • Alzheimer Disease
  • Cerebral Cortex
  • Cortical Synchronization
  • Electroencephalography
  • Female
  • Humans
  • Lewy Body Disease
  • Male
  • Ocular Physiological Phenomena
  • Rest
  • Retrospective Studies

Cite this

Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study. / Babiloni, C.; Del Percio, C.; Lizio, R.; Noce, G.; Cordone, S.; Lopez, S.; Soricelli, A.; Ferri, R.; Pascarelli, M.T.; Nobili, F.; Arnaldi, D.; Aarsland, D.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Onofrj, M.; Stocchi, F.; Stirpe, P.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Caravias, G.; Garn, H.; Sorpresi, F.; Pievani, M.; Frisoni, G.B.; D'Antonio, F.; De Lena, C.; Güntekin, B.; Hanoğlu, L.; Başar, E.; Yener, G.; Emek-Savaş, D.D.; Triggiani, A.I.; Franciotti, R.; De Pandis, M.F.; Bonanni, L.

In: Neurobiology of Aging, Vol. 55, 2017, p. 143-158.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Cordone, S, Lopez, S, Soricelli, A, Ferri, R, Pascarelli, MT, Nobili, F, Arnaldi, D, Aarsland, D, Orzi, F, Buttinelli, C, Giubilei, F, Onofrj, M, Stocchi, F, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Caravias, G, Garn, H, Sorpresi, F, Pievani, M, Frisoni, GB, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Başar, E, Yener, G, Emek-Savaş, DD, Triggiani, AI, Franciotti, R, De Pandis, MF & Bonanni, L 2017, 'Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study', Neurobiology of Aging, vol. 55, pp. 143-158. https://doi.org/10.1016/j.neurobiolaging.2017.03.030
Babiloni, C. ; Del Percio, C. ; Lizio, R. ; Noce, G. ; Cordone, S. ; Lopez, S. ; Soricelli, A. ; Ferri, R. ; Pascarelli, M.T. ; Nobili, F. ; Arnaldi, D. ; Aarsland, D. ; Orzi, F. ; Buttinelli, C. ; Giubilei, F. ; Onofrj, M. ; Stocchi, F. ; Stirpe, P. ; Fuhr, P. ; Gschwandtner, U. ; Ransmayr, G. ; Caravias, G. ; Garn, H. ; Sorpresi, F. ; Pievani, M. ; Frisoni, G.B. ; D'Antonio, F. ; De Lena, C. ; Güntekin, B. ; Hanoğlu, L. ; Başar, E. ; Yener, G. ; Emek-Savaş, D.D. ; Triggiani, A.I. ; Franciotti, R. ; De Pandis, M.F. ; Bonanni, L. / Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study. In: Neurobiology of Aging. 2017 ; Vol. 55. pp. 143-158.
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title = "Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study",
abstract = "The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini–Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85–0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery. {\circledC} 2017 Elsevier Inc.",
keywords = "Alzheimer's disease dementia (ADD), Dementia with Lewy body (DLB), Exact low-resolution brain electromagnetic source tomography (eLORETA), Parkinson's disease dementia (PDD), Resting state electroencephalographic (rsEEG) rhythms, aged, alpha rhythm, Alzheimer disease, arousal, Article, beta rhythm, controlled study, cortical synchronization, delta rhythm, diffuse Lewy body disease, educational status, electroencephalogram, exploratory research, female, human, major clinical study, male, measurement accuracy, Mini Mental State Examination, occipital lobe, Parkinson disease, priority journal, receiver operating characteristic, retrospective study, sensitivity and specificity, theta rhythm, wakefulness, brain cortex, electroencephalography, pathophysiology, physiology, rest, visual system function, Aged, Alzheimer Disease, Cerebral Cortex, Cortical Synchronization, Electroencephalography, Female, Humans, Lewy Body Disease, Male, Ocular Physiological Phenomena, Rest, Retrospective Studies",
author = "C. Babiloni and {Del Percio}, C. and R. Lizio and G. Noce and S. Cordone and S. Lopez and A. Soricelli and R. Ferri and M.T. Pascarelli and F. Nobili and D. Arnaldi and D. Aarsland and F. Orzi and C. Buttinelli and F. Giubilei and M. Onofrj and F. Stocchi and P. Stirpe and P. Fuhr and U. Gschwandtner and G. Ransmayr and G. Caravias and H. Garn and F. Sorpresi and M. Pievani and G.B. Frisoni and F. D'Antonio and {De Lena}, C. and B. G{\"u}ntekin and L. Hanoğlu and E. Başar and G. Yener and D.D. Emek-Savaş and A.I. Triggiani and R. Franciotti and {De Pandis}, M.F. and L. Bonanni",
note = "Cited By :2 Export Date: 5 March 2018 CODEN: NEAGD Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer”, University of Rome “La Sapienza”, P. le A. Moro 5, Italy; email: claudio.babiloni@uniroma1.it References: Aarsland, D., Litvan, I., Salmon, D., Galasko, D., Wentzel-Larsen, T., Larsen, J.P., Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease (2003) J. Neurol. Neurosurg. Psychiatry, 74, pp. 1215-1220; Adler, G., Brassen, S., Jajcevic, A., EEG coherence in Alzheimer's dementia (2003) J. Neural. Transm., 110, pp. 1051-1058; Agosta, F., Canu, E., Stefanova, E., Sarro, L., Tomić, A., Špica, V., Comi, G., Filippi, M., Mild cognitive impairment in Parkinson's disease is associated with a distributed pattern of brain white matter damage (2014) Hum. 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year = "2017",
doi = "10.1016/j.neurobiolaging.2017.03.030",
language = "English",
volume = "55",
pages = "143--158",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

AU - Babiloni, C.

AU - Del Percio, C.

AU - Lizio, R.

AU - Noce, G.

AU - Cordone, S.

AU - Lopez, S.

AU - Soricelli, A.

AU - Ferri, R.

AU - Pascarelli, M.T.

AU - Nobili, F.

AU - Arnaldi, D.

AU - Aarsland, D.

AU - Orzi, F.

AU - Buttinelli, C.

AU - Giubilei, F.

AU - Onofrj, M.

AU - Stocchi, F.

AU - Stirpe, P.

AU - Fuhr, P.

AU - Gschwandtner, U.

AU - Ransmayr, G.

AU - Caravias, G.

AU - Garn, H.

AU - Sorpresi, F.

AU - Pievani, M.

AU - Frisoni, G.B.

AU - D'Antonio, F.

AU - De Lena, C.

AU - Güntekin, B.

AU - Hanoğlu, L.

AU - Başar, E.

AU - Yener, G.

AU - Emek-Savaş, D.D.

AU - Triggiani, A.I.

AU - Franciotti, R.

AU - De Pandis, M.F.

AU - Bonanni, L.

N1 - Cited By :2 Export Date: 5 March 2018 CODEN: NEAGD Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer”, University of Rome “La Sapienza”, P. le A. Moro 5, Italy; email: claudio.babiloni@uniroma1.it References: Aarsland, D., Litvan, I., Salmon, D., Galasko, D., Wentzel-Larsen, T., Larsen, J.P., Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease (2003) J. Neurol. Neurosurg. Psychiatry, 74, pp. 1215-1220; Adler, G., Brassen, S., Jajcevic, A., EEG coherence in Alzheimer's dementia (2003) J. Neural. Transm., 110, pp. 1051-1058; Agosta, F., Canu, E., Stefanova, E., Sarro, L., Tomić, A., Špica, V., Comi, G., Filippi, M., Mild cognitive impairment in Parkinson's disease is associated with a distributed pattern of brain white matter damage (2014) Hum. 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PY - 2017

Y1 - 2017

N2 - The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini–Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85–0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery. © 2017 Elsevier Inc.

AB - The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini–Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85–0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery. © 2017 Elsevier Inc.

KW - Alzheimer's disease dementia (ADD)

KW - Dementia with Lewy body (DLB)

KW - Exact low-resolution brain electromagnetic source tomography (eLORETA)

KW - Parkinson's disease dementia (PDD)

KW - Resting state electroencephalographic (rsEEG) rhythms

KW - aged

KW - alpha rhythm

KW - Alzheimer disease

KW - arousal

KW - Article

KW - beta rhythm

KW - controlled study

KW - cortical synchronization

KW - delta rhythm

KW - diffuse Lewy body disease

KW - educational status

KW - electroencephalogram

KW - exploratory research

KW - female

KW - human

KW - major clinical study

KW - male

KW - measurement accuracy

KW - Mini Mental State Examination

KW - occipital lobe

KW - Parkinson disease

KW - priority journal

KW - receiver operating characteristic

KW - retrospective study

KW - sensitivity and specificity

KW - theta rhythm

KW - wakefulness

KW - brain cortex

KW - electroencephalography

KW - pathophysiology

KW - physiology

KW - rest

KW - visual system function

KW - Aged

KW - Alzheimer Disease

KW - Cerebral Cortex

KW - Cortical Synchronization

KW - Electroencephalography

KW - Female

KW - Humans

KW - Lewy Body Disease

KW - Male

KW - Ocular Physiological Phenomena

KW - Rest

KW - Retrospective Studies

U2 - 10.1016/j.neurobiolaging.2017.03.030

DO - 10.1016/j.neurobiolaging.2017.03.030

M3 - Article

VL - 55

SP - 143

EP - 158

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -