Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

C. Babiloni, C. Del Percio, R. Lizio, G. Noce, S. Cordone, S. Lopez, A. Soricelli, R. Ferri, M.T. Pascarelli, F. Nobili, D. Arnaldi, D. Aarsland, F. Orzi, C. Buttinelli, F. Giubilei, M. Onofrj, F. Stocchi, P. Stirpe, P. Fuhr, U. GschwandtnerG. Ransmayr, G. Caravias, H. Garn, F. Sorpresi, M. Pievani, G.B. Frisoni, F. D'Antonio, C. De Lena, B. Güntekin, L. Hanoğlu, E. Başar, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, R. Franciotti, M.F. De Pandis, L. Bonanni

Research output: Contribution to journalArticle

Abstract

The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini–Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85–0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery. © 2017 Elsevier Inc.
Original languageEnglish
Pages (from-to)143-158
Number of pages16
JournalNeurobiology of Aging
Volume55
DOIs
Publication statusPublished - 2017

Keywords

  • Alzheimer's disease dementia (ADD)
  • Dementia with Lewy body (DLB)
  • Exact low-resolution brain electromagnetic source tomography (eLORETA)
  • Parkinson's disease dementia (PDD)
  • Resting state electroencephalographic (rsEEG) rhythms
  • aged
  • alpha rhythm
  • Alzheimer disease
  • arousal
  • Article
  • beta rhythm
  • controlled study
  • cortical synchronization
  • delta rhythm
  • diffuse Lewy body disease
  • educational status
  • electroencephalogram
  • exploratory research
  • female
  • human
  • major clinical study
  • male
  • measurement accuracy
  • Mini Mental State Examination
  • occipital lobe
  • Parkinson disease
  • priority journal
  • receiver operating characteristic
  • retrospective study
  • sensitivity and specificity
  • theta rhythm
  • wakefulness
  • brain cortex
  • electroencephalography
  • pathophysiology
  • physiology
  • rest
  • visual system function
  • Aged
  • Alzheimer Disease
  • Cerebral Cortex
  • Cortical Synchronization
  • Electroencephalography
  • Female
  • Humans
  • Lewy Body Disease
  • Male
  • Ocular Physiological Phenomena
  • Rest
  • Retrospective Studies

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