TY - JOUR
T1 - Abnormalities of Cortical Sources of Resting State Alpha Electroencephalographic Rhythms are Related to Education Attainment in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment
AU - Babiloni, Claudio
AU - Ferri, Raffaele
AU - Noce, Giuseppe
AU - Lizio, Roberta
AU - Lopez, Susanna
AU - Lorenzo, Ivan
AU - Panzavolta, Andrea
AU - Soricelli, Andrea
AU - Nobili, Flavio
AU - Arnaldi, Dario
AU - Famà, Francesco
AU - Orzi, Francesco
AU - Buttinelli, Carla
AU - Giubilei, Franco
AU - Cipollini, Virginia
AU - Marizzoni, Moira
AU - Güntekin, Bahar
AU - Aktürk, Tuba
AU - Hanoğlu, Lutfu
AU - Yener, Görsev
AU - Özbek, Yağmur
AU - Stocchi, Fabrizio
AU - Vacca, Laura
AU - Frisoni, Giovanni B.
AU - Del Percio, Claudio
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/3/5
Y1 - 2021/3/5
N2 - In normal old (Nold) and Alzheimer's disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here, we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythms in Nold and patients with mild cognitive impairment (MCI) due to AD (ADMCI). Data in 60 Nold and 70 ADMCI participants, stratified in higher (Edu+) and lower (Edu-) educational attainment subgroups, were available in an Italian-Turkish archive. The subgroups were matched for age, gender, and education. RsEEG cortical sources were estimated by eLORETA freeware. As compared to the Nold-Edu- subgroup, the Nold-Edu+ subgroup showed greater alpha source activations topographically widespread. On the contrary, in relation to the ADMCI-Edu- subgroup, the ADMCI-Edu+ subgroup displayed lower alpha source activations topographically widespread. Furthermore, the 2 ADMCI subgroups had matched cerebrospinal AD diagnostic biomarkers, brain gray-white matter measures, and neuropsychological scores. The current findings suggest that a high CR may be related to changes in rsEEG alpha rhythms in Nold and ADMCI persons. These changes may underlie neuroprotective effects in Nold seniors and subtend functional compensatory mechanisms unrelated to brain structure alterations in ADMCI patients.
AB - In normal old (Nold) and Alzheimer's disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here, we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythms in Nold and patients with mild cognitive impairment (MCI) due to AD (ADMCI). Data in 60 Nold and 70 ADMCI participants, stratified in higher (Edu+) and lower (Edu-) educational attainment subgroups, were available in an Italian-Turkish archive. The subgroups were matched for age, gender, and education. RsEEG cortical sources were estimated by eLORETA freeware. As compared to the Nold-Edu- subgroup, the Nold-Edu+ subgroup showed greater alpha source activations topographically widespread. On the contrary, in relation to the ADMCI-Edu- subgroup, the ADMCI-Edu+ subgroup displayed lower alpha source activations topographically widespread. Furthermore, the 2 ADMCI subgroups had matched cerebrospinal AD diagnostic biomarkers, brain gray-white matter measures, and neuropsychological scores. The current findings suggest that a high CR may be related to changes in rsEEG alpha rhythms in Nold and ADMCI persons. These changes may underlie neuroprotective effects in Nold seniors and subtend functional compensatory mechanisms unrelated to brain structure alterations in ADMCI patients.
KW - aging
KW - education attainment
KW - exact low-resolution brain electromagnetic source tomography (eLORETA)
KW - mild cognitive impairment due to Alzheimer’s disease (ADMCI)
KW - resting state electroencephalographic (rsEEG) rhythms
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U2 - 10.1093/cercor/bhaa356
DO - 10.1093/cercor/bhaa356
M3 - Article
AN - SCOPUS:85102910430
VL - 31
SP - 2220
EP - 2237
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 4
ER -