TY - JOUR
T1 - Abnormalities of Cortical Sources of Resting State Delta Electroencephalographic Rhythms Are Related to Epileptiform Activity in Patients With Amnesic Mild Cognitive Impairment Not Due to Alzheimer's Disease
AU - Babiloni, Claudio
AU - Noce, Giuseppe
AU - Di Bonaventura, Carlo
AU - Lizio, Roberta
AU - Pascarelli, Maria Teresa
AU - Tucci, Federico
AU - Soricelli, Andrea
AU - Ferri, Raffaele
AU - Nobili, Flavio
AU - Famà, Francesco
AU - Palma, Eleonora
AU - Cifelli, Pierangelo
AU - Marizzoni, Moira
AU - Stocchi, Fabrizio
AU - Frisoni, Giovanni B.
AU - Del Percio, Claudio
N1 - Funding Information:
The Authors thank Dott. Ali Eldellaa, MD, for his support in the data management. The present study was developed based on the data of the European-Asiatic Consortium PDWAVES and European Consortia of Dementia with Lewy Body and FP7-IMI PharmaCog (www.pharmacog.org) projects. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. In this study, the electroencephalographic data analysis was partially supported by the funds of Ricerca Corrente attributed by Italian Ministry of Health to the IRCCS SDN of Naples, IRCCS OASI of Troina, and IRCCS San Raffaele Pisana of Rome.
Publisher Copyright:
© Copyright © 2020 Babiloni, Noce, Di Bonaventura, Lizio, Pascarelli, Tucci, Soricelli, Ferri, Nobili, Famà, Palma, Cifelli, Marizzoni, Stocchi, Frisoni and Del Percio.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/23
Y1 - 2020/10/23
N2 - In the present exploratory and retrospective study, we hypothesized that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might be more abnormal in patients with epileptiform EEG activity (spike-sharp wave discharges, giant spikes) and amnesic mild cognitive impairment not due to Alzheimer's disease (noADMCI-EEA) than matched noADMCI patients without EEA (noADMCI-noEEA). Clinical, neuroimaging, neuropsychological, and rsEEG data in 32 noADMCI and 30 normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were carefully matched among them. No subject had received a clinical diagnosis of epilepsy. Individual alpha frequency peak (IAF) was used to determine the delta, theta, and alpha frequency bands of rsEEG rhythms. Fixed beta and gamma bands were also considered. Regional rsEEG cortical sources were estimated by eLORETA freeware. Area under receiver operating characteristic (AUROC) curves indexed the accuracy of eLORETA solutions in the classification between noADMCI-EEA and noADMCI-noEEA individuals. As novel findings, EEA was observed in 41% of noADMCI patients. Furthermore, these noADMCI-EEA patients showed higher temporal delta source activities as compared to noADMCI-no EEA patients and Nold subjects. Those activities discriminated individuals of the two NoADMCI groups with an accuracy of about 70%. The significant percentage of noADMCI-EEA patients showing EEA and marked abnormalities in temporal rsEEG rhythms at delta frequencies suggest a substantial role of underlying neural hypersynchronization mechanisms in their brain dysfunctions.
AB - In the present exploratory and retrospective study, we hypothesized that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might be more abnormal in patients with epileptiform EEG activity (spike-sharp wave discharges, giant spikes) and amnesic mild cognitive impairment not due to Alzheimer's disease (noADMCI-EEA) than matched noADMCI patients without EEA (noADMCI-noEEA). Clinical, neuroimaging, neuropsychological, and rsEEG data in 32 noADMCI and 30 normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were carefully matched among them. No subject had received a clinical diagnosis of epilepsy. Individual alpha frequency peak (IAF) was used to determine the delta, theta, and alpha frequency bands of rsEEG rhythms. Fixed beta and gamma bands were also considered. Regional rsEEG cortical sources were estimated by eLORETA freeware. Area under receiver operating characteristic (AUROC) curves indexed the accuracy of eLORETA solutions in the classification between noADMCI-EEA and noADMCI-noEEA individuals. As novel findings, EEA was observed in 41% of noADMCI patients. Furthermore, these noADMCI-EEA patients showed higher temporal delta source activities as compared to noADMCI-no EEA patients and Nold subjects. Those activities discriminated individuals of the two NoADMCI groups with an accuracy of about 70%. The significant percentage of noADMCI-EEA patients showing EEA and marked abnormalities in temporal rsEEG rhythms at delta frequencies suggest a substantial role of underlying neural hypersynchronization mechanisms in their brain dysfunctions.
KW - alzheheimer's disease
KW - amnesic mild cognitive impairment (aMCI)
KW - dementia
KW - epileptiform electroencephalographic activity (EEA)
KW - exact low-resolution brain electromagnetic source tomography (eLORETA)
KW - resting state electroencephalographic (rsEEG) rhythms
UR - http://www.scopus.com/inward/record.url?scp=85095601099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85095601099&partnerID=8YFLogxK
U2 - 10.3389/fneur.2020.514136
DO - 10.3389/fneur.2020.514136
M3 - Article
AN - SCOPUS:85095601099
VL - 11
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
M1 - 514136
ER -