Abstract
| Original language | English |
|---|---|
| Article number | 514136 |
| Journal | Front. Neurol. |
| Volume | 11 |
| DOIs | |
| Publication status | Published - 2020 |
Keywords
- alzheheimer's disease
- amnesic mild cognitive impairment (aMCI)
- dementia
- epileptiform electroencephalographic activity (EEA)
- exact low-resolution brain electromagnetic source tomography (eLORETA)
- resting state electroencephalographic (rsEEG) rhythms
- alprazolam
- amyloid beta protein[1-42]
- apolipoprotein E4
- bromazepam
- citalopram
- diazepam
- donepezil
- escitalopram
- lorazepam
- midazolam
- rivastigmine
- sertraline
- tau protein
- venlafaxine
- zolpidem
- aged
- alpha rhythm
- APOE4 gene
- Article
- beta rhythm
- cerebrospinal fluid analysis
- clinical article
- controlled study
- delta rhythm
- diagnostic accuracy
- diagnostic test accuracy study
- drug use
- EEG abnormality
- epileptic discharge
- exploratory research
- female
- gamma rhythm
- human
- male
- mild cognitive impairment
- predictive value
- receiver operating characteristic
- retrospective study
- sensitivity and specificity
- software
- spike wave
- theta rhythm
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Abnormalities of Cortical Sources of Resting State Delta Electroencephalographic Rhythms Are Related to Epileptiform Activity in Patients With Amnesic Mild Cognitive Impairment Not Due to Alzheimer's Disease. / Babiloni, C.; Noce, G.; Di Bonaventura, C.; Lizio, R.; Pascarelli, M.T.; Tucci, F.; Soricelli, A.; Ferri, R.; Nobili, F.; Famà, F.; Palma, E.; Cifelli, P.; Marizzoni, M.; Stocchi, F.; Frisoni, G.B.; Del Percio, C.
In: Front. Neurol., Vol. 11, 514136, 2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Abnormalities of Cortical Sources of Resting State Delta Electroencephalographic Rhythms Are Related to Epileptiform Activity in Patients With Amnesic Mild Cognitive Impairment Not Due to Alzheimer's Disease
AU - Babiloni, C.
AU - Noce, G.
AU - Di Bonaventura, C.
AU - Lizio, R.
AU - Pascarelli, M.T.
AU - Tucci, F.
AU - Soricelli, A.
AU - Ferri, R.
AU - Nobili, F.
AU - Famà, F.
AU - Palma, E.
AU - Cifelli, P.
AU - Marizzoni, M.
AU - Stocchi, F.
AU - Frisoni, G.B.
AU - Del Percio, C.
N1 - Export Date: 23 February 2021 Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology, Italy; email: claudio.babiloni@uniroma1.it Correspondence Address: Babiloni, C.; San Raffaele CassinoItaly; email: claudio.babiloni@uniroma1.it Chemicals/CAS: alprazolam, 28981-97-7; bromazepam, 1812-30-2; citalopram, 59729-33-8, 59729-32-7; diazepam, 439-14-5; donepezil, 120011-70-3, 120014-06-4, 142057-77-0; escitalopram, 128196-01-0, 219861-08-2; lorazepam, 846-49-1; midazolam, 59467-70-8; rivastigmine, 129101-54-8, 123441-03-2; sertraline, 79617-96-2, 79559-97-0; venlafaxine, 93413-69-5, 99300-78-4; zolpidem, 82626-48-0 Funding text 1: The Authors thank Dott. Ali Eldellaa, MD, for his support in the data management. The present study was developed based on the data of the European-Asiatic Consortium PDWAVES and European Consortia of Dementia with Lewy Body and FP7-IMI PharmaCog (www.pharmacog.org) projects. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. In this study, the electroencephalographic data analysis was partially supported by the funds of Ricerca Corrente attributed by Italian Ministry of Health to the IRCCS SDN of Naples, IRCCS OASI of Troina, and IRCCS San Raffaele Pisana of Rome. References: Dubois, B., Feldman, H.H., Jacova, C., Hampel, H., Molinuevo, J.L., Blennow, K., Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria (2014) Lancet Neurol, 13, pp. 614-629. , 24849862; Scarmeas, N., Honig, L.S., Choi, H., Cantero, J., Brandt, J., Blacker, D., Seizures in Alzheimer disease: who, when, and how common? 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PY - 2020
Y1 - 2020
N2 - In the present exploratory and retrospective study, we hypothesized that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might be more abnormal in patients with epileptiform EEG activity (spike-sharp wave discharges, giant spikes) and amnesic mild cognitive impairment not due to Alzheimer's disease (noADMCI-EEA) than matched noADMCI patients without EEA (noADMCI-noEEA). Clinical, neuroimaging, neuropsychological, and rsEEG data in 32 noADMCI and 30 normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were carefully matched among them. No subject had received a clinical diagnosis of epilepsy. Individual alpha frequency peak (IAF) was used to determine the delta, theta, and alpha frequency bands of rsEEG rhythms. Fixed beta and gamma bands were also considered. Regional rsEEG cortical sources were estimated by eLORETA freeware. Area under receiver operating characteristic (AUROC) curves indexed the accuracy of eLORETA solutions in the classification between noADMCI-EEA and noADMCI-noEEA individuals. As novel findings, EEA was observed in 41% of noADMCI patients. Furthermore, these noADMCI-EEA patients showed higher temporal delta source activities as compared to noADMCI-no EEA patients and Nold subjects. Those activities discriminated individuals of the two NoADMCI groups with an accuracy of about 70%. The significant percentage of noADMCI-EEA patients showing EEA and marked abnormalities in temporal rsEEG rhythms at delta frequencies suggest a substantial role of underlying neural hypersynchronization mechanisms in their brain dysfunctions. © Copyright © 2020 Babiloni, Noce, Di Bonaventura, Lizio, Pascarelli, Tucci, Soricelli, Ferri, Nobili, Famà, Palma, Cifelli, Marizzoni, Stocchi, Frisoni and Del Percio.
AB - In the present exploratory and retrospective study, we hypothesized that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might be more abnormal in patients with epileptiform EEG activity (spike-sharp wave discharges, giant spikes) and amnesic mild cognitive impairment not due to Alzheimer's disease (noADMCI-EEA) than matched noADMCI patients without EEA (noADMCI-noEEA). Clinical, neuroimaging, neuropsychological, and rsEEG data in 32 noADMCI and 30 normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were carefully matched among them. No subject had received a clinical diagnosis of epilepsy. Individual alpha frequency peak (IAF) was used to determine the delta, theta, and alpha frequency bands of rsEEG rhythms. Fixed beta and gamma bands were also considered. Regional rsEEG cortical sources were estimated by eLORETA freeware. Area under receiver operating characteristic (AUROC) curves indexed the accuracy of eLORETA solutions in the classification between noADMCI-EEA and noADMCI-noEEA individuals. As novel findings, EEA was observed in 41% of noADMCI patients. Furthermore, these noADMCI-EEA patients showed higher temporal delta source activities as compared to noADMCI-no EEA patients and Nold subjects. Those activities discriminated individuals of the two NoADMCI groups with an accuracy of about 70%. The significant percentage of noADMCI-EEA patients showing EEA and marked abnormalities in temporal rsEEG rhythms at delta frequencies suggest a substantial role of underlying neural hypersynchronization mechanisms in their brain dysfunctions. © Copyright © 2020 Babiloni, Noce, Di Bonaventura, Lizio, Pascarelli, Tucci, Soricelli, Ferri, Nobili, Famà, Palma, Cifelli, Marizzoni, Stocchi, Frisoni and Del Percio.
KW - alzheheimer's disease
KW - amnesic mild cognitive impairment (aMCI)
KW - dementia
KW - epileptiform electroencephalographic activity (EEA)
KW - exact low-resolution brain electromagnetic source tomography (eLORETA)
KW - resting state electroencephalographic (rsEEG) rhythms
KW - alprazolam
KW - amyloid beta protein[1-42]
KW - apolipoprotein E4
KW - bromazepam
KW - citalopram
KW - diazepam
KW - donepezil
KW - escitalopram
KW - lorazepam
KW - midazolam
KW - rivastigmine
KW - sertraline
KW - tau protein
KW - venlafaxine
KW - zolpidem
KW - aged
KW - alpha rhythm
KW - APOE4 gene
KW - Article
KW - beta rhythm
KW - cerebrospinal fluid analysis
KW - clinical article
KW - controlled study
KW - delta rhythm
KW - diagnostic accuracy
KW - diagnostic test accuracy study
KW - drug use
KW - EEG abnormality
KW - epileptic discharge
KW - exploratory research
KW - female
KW - gamma rhythm
KW - human
KW - male
KW - mild cognitive impairment
KW - predictive value
KW - receiver operating characteristic
KW - retrospective study
KW - sensitivity and specificity
KW - software
KW - spike wave
KW - theta rhythm
U2 - 10.3389/fneur.2020.514136
DO - 10.3389/fneur.2020.514136
M3 - Article
VL - 11
JO - Front. Neurol.
JF - Front. Neurol.
SN - 1664-2295
M1 - 514136
ER -