Abnormalities of endothelial function in the pathogenesis of stroke: The importance of endothelin

M. Volpe, F. Cosentino

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelial cells play a key role in the local regulation of the vascular smooth muscle tone by producing and releasing relaxing and contracting factors. Endothelin (ET)-1, one of the most potent endogenous vasoconstrictor substances known, is produced by endothelial cells. In the cerebral vasculature ET-1 is thought to be involved in several pathological conditions, including vasospasm following subarachnoid hemorrhage and stroke. This review contains evidence suggesting that endothelial dysfunction may contribute to the development of ischemic stroke and discusses the current knowledge concerning the role of ET-1 in the pathogenesis of stroke in animal models and in humans.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume35
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2000

Keywords

  • Atrial natriuretic peptide
  • Cerebral circulation
  • Endothelial dysfunction
  • Endothelin A and B receptors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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