TY - JOUR
T1 - Abnormalities of endothelial function in the pathogenesis of stroke
T2 - The importance of endothelin
AU - Volpe, M.
AU - Cosentino, F.
PY - 2000
Y1 - 2000
N2 - Endothelial cells play a key role in the local regulation of the vascular smooth muscle tone by producing and releasing relaxing and contracting factors. Endothelin (ET)-1, one of the most potent endogenous vasoconstrictor substances known, is produced by endothelial cells. In the cerebral vasculature ET-1 is thought to be involved in several pathological conditions, including vasospasm following subarachnoid hemorrhage and stroke. This review contains evidence suggesting that endothelial dysfunction may contribute to the development of ischemic stroke and discusses the current knowledge concerning the role of ET-1 in the pathogenesis of stroke in animal models and in humans.
AB - Endothelial cells play a key role in the local regulation of the vascular smooth muscle tone by producing and releasing relaxing and contracting factors. Endothelin (ET)-1, one of the most potent endogenous vasoconstrictor substances known, is produced by endothelial cells. In the cerebral vasculature ET-1 is thought to be involved in several pathological conditions, including vasospasm following subarachnoid hemorrhage and stroke. This review contains evidence suggesting that endothelial dysfunction may contribute to the development of ischemic stroke and discusses the current knowledge concerning the role of ET-1 in the pathogenesis of stroke in animal models and in humans.
KW - Atrial natriuretic peptide
KW - Cerebral circulation
KW - Endothelial dysfunction
KW - Endothelin A and B receptors
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U2 - 10.1097/00005344-200000002-00011
DO - 10.1097/00005344-200000002-00011
M3 - Article
C2 - 10976781
AN - SCOPUS:0033652990
VL - 35
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - SUPPL. 2
ER -