Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Claudio Babiloni, Claudio Del Percio, Maria Teresa Pascarelli, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Marco Rizzo, Raffaele Ferri, Andrea Soricelli, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Salvetti, Virginia Cipollini, Raffaella Franciotti, Marco Onofrj, Paola Stirpe & 22 others Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Dag Aarsland, Lucilla Parnetti, Lucia Farotti, Moira Marizzoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Harald Hampel, Giovanni B. Frisoni, Maria Francesca De Pandis, Laura Bonanni

Research output: Contribution to journalArticle

Abstract

Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8–10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72–0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.

Original languageEnglish
Pages (from-to)112-127
Number of pages16
JournalNeurobiology of Aging
Volume77
DOIs
Publication statusPublished - May 1 2019

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Alpha Rhythm
Lewy Body Disease
Prodromal Symptoms
Lewy Bodies
Dementia
ROC Curve
Cholinergic Agents
Education
Cognitive Dysfunction

Keywords

  • Functional brain connectivity
  • Mild cognitive impairment due to Alzheimer's disease (ADMCI)
  • Mild cognitive impairment due to dementia with Lewy body (DLBMCI)
  • Resting state EEG rhythms

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. / Babiloni, Claudio; Del Percio, Claudio; Pascarelli, Maria Teresa; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Rizzo, Marco; Ferri, Raffaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Salvetti, Marco; Cipollini, Virginia; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Farotti, Lucia; Marizzoni, Moira; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Hampel, Harald; Frisoni, Giovanni B.; De Pandis, Maria Francesca; Bonanni, Laura.

In: Neurobiology of Aging, Vol. 77, 01.05.2019, p. 112-127.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Pascarelli, MT, Lizio, R, Noce, G, Lopez, S, Rizzo, M, Ferri, R, Soricelli, A, Nobili, F, Arnaldi, D, Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Salvetti, M, Cipollini, V, Franciotti, R, Onofrj, M, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Aarsland, D, Parnetti, L, Farotti, L, Marizzoni, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Yener, G, Emek-Savaş, DD, Triggiani, AI, Taylor, JP, McKeith, I, Stocchi, F, Vacca, L, Hampel, H, Frisoni, GB, De Pandis, MF & Bonanni, L 2019, 'Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases', Neurobiology of Aging, vol. 77, pp. 112-127. https://doi.org/10.1016/j.neurobiolaging.2019.01.013
Babiloni, Claudio ; Del Percio, Claudio ; Pascarelli, Maria Teresa ; Lizio, Roberta ; Noce, Giuseppe ; Lopez, Susanna ; Rizzo, Marco ; Ferri, Raffaele ; Soricelli, Andrea ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco ; Orzi, Francesco ; Buttinelli, Carla ; Giubilei, Franco ; Salvetti, Marco ; Cipollini, Virginia ; Franciotti, Raffaella ; Onofrj, Marco ; Stirpe, Paola ; Fuhr, Peter ; Gschwandtner, Ute ; Ransmayr, Gerhard ; Aarsland, Dag ; Parnetti, Lucilla ; Farotti, Lucia ; Marizzoni, Moira ; D'Antonio, Fabrizia ; De Lena, Carlo ; Güntekin, Bahar ; Hanoğlu, Lutfu ; Yener, Görsev ; Emek-Savaş, Derya Durusu ; Triggiani, Antonio Ivano ; Taylor, John Paul ; McKeith, Ian ; Stocchi, Fabrizio ; Vacca, Laura ; Hampel, Harald ; Frisoni, Giovanni B. ; De Pandis, Maria Francesca ; Bonanni, Laura. / Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. In: Neurobiology of Aging. 2019 ; Vol. 77. pp. 112-127.
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abstract = "Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8–10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72–0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.",
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T1 - Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

AU - Babiloni, Claudio

AU - Del Percio, Claudio

AU - Pascarelli, Maria Teresa

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Rizzo, Marco

AU - Ferri, Raffaele

AU - Soricelli, Andrea

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Orzi, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Salvetti, Marco

AU - Cipollini, Virginia

AU - Franciotti, Raffaella

AU - Onofrj, Marco

AU - Stirpe, Paola

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Aarsland, Dag

AU - Parnetti, Lucilla

AU - Farotti, Lucia

AU - Marizzoni, Moira

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanoğlu, Lutfu

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Triggiani, Antonio Ivano

AU - Taylor, John Paul

AU - McKeith, Ian

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Hampel, Harald

AU - Frisoni, Giovanni B.

AU - De Pandis, Maria Francesca

AU - Bonanni, Laura

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8–10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72–0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.

AB - Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8–10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72–0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.

KW - Functional brain connectivity

KW - Mild cognitive impairment due to Alzheimer's disease (ADMCI)

KW - Mild cognitive impairment due to dementia with Lewy body (DLBMCI)

KW - Resting state EEG rhythms

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