Abnormalities of gastrointestinal motility in children with nonulcer dyspepsia and in children with gastroesophageal reflux disease

S. Cucchiara, M. Bortolotti, C. Colombo, A. Boccieri, M. De Stefano, G. Vitiello, A. Pagano, A. Ronchi, S. Auricchio

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

In 11 children (mean age 44.2 months) with symptoms suggesting upper intestinal dysfunction (nonulcer dyspepsia), in nine children (mean age 27.3 months) with gastroesophageal reflux (GER) disease, and in seven controls (mean age 20.4 months) we investigated fasting [for 3 hr or until two migrating motor complexes (MMC) were observed] and fed (90 min) antroduodenal motility by means of perfused catheter system; furthermore, we measured both gastric emptying of a radiolabeled milk formula and fasting duodenogastric reflux during manometry by assessing bile salt concentration in gastric aspirates. No structural abnormalities of gastrointestinal tract and organic disorders were detected in the patients. In a high proportion of both groups of patients we found manometric abnormalities of interdigestive and fed motor patterns that were not seen in the controls: absence of antral phase III of MMC; significant decrease of antral and/or duodenal motor activity during fasting and/or fed periods; abnormal propagation or configuration of MMC phase III that was signficantly shorter than in controls; bursts of sustained fasting and/or fed phasic duodenal activity, frequently uncoordinated with adjacent gut segments. When compared to controls, the mean intragastric concentration of bile salts during all MMC phases and the mean 1-hr percent gastric activity of the radiolabeled milk were significantly higher in the two groups of patients. We conclude that in a high proportion of children with nonulcer dyspepsia and of children with GER disease, gastrointestinal manometry may reveal significant irregularities of antral and duodenal motility, which are associated with increased duodenogastric reflux and delayed gastric emptying.

Original languageEnglish
Pages (from-to)1066-1073
Number of pages8
JournalDigestive Diseases and Sciences
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 1991

Fingerprint

Migrating Myoelectric Complexes
Gastrointestinal Motility
Dyspepsia
Gastroesophageal Reflux
Fasting
Duodenogastric Reflux
Gastric Emptying
Manometry
Bile Acids and Salts
Stomach
Milk
Gastrointestinal Tract
Motor Activity
Catheters
Antral

Keywords

  • bile salt concentration
  • gastric emptying
  • migrating motor complexes
  • nonulcer dyspepsia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Abnormalities of gastrointestinal motility in children with nonulcer dyspepsia and in children with gastroesophageal reflux disease. / Cucchiara, S.; Bortolotti, M.; Colombo, C.; Boccieri, A.; De Stefano, M.; Vitiello, G.; Pagano, A.; Ronchi, A.; Auricchio, S.

In: Digestive Diseases and Sciences, Vol. 36, No. 8, 08.1991, p. 1066-1073.

Research output: Contribution to journalArticle

Cucchiara, S, Bortolotti, M, Colombo, C, Boccieri, A, De Stefano, M, Vitiello, G, Pagano, A, Ronchi, A & Auricchio, S 1991, 'Abnormalities of gastrointestinal motility in children with nonulcer dyspepsia and in children with gastroesophageal reflux disease', Digestive Diseases and Sciences, vol. 36, no. 8, pp. 1066-1073. https://doi.org/10.1007/BF01297448
Cucchiara, S. ; Bortolotti, M. ; Colombo, C. ; Boccieri, A. ; De Stefano, M. ; Vitiello, G. ; Pagano, A. ; Ronchi, A. ; Auricchio, S. / Abnormalities of gastrointestinal motility in children with nonulcer dyspepsia and in children with gastroesophageal reflux disease. In: Digestive Diseases and Sciences. 1991 ; Vol. 36, No. 8. pp. 1066-1073.
@article{6c73c29d495d446ba15436e47ea05817,
title = "Abnormalities of gastrointestinal motility in children with nonulcer dyspepsia and in children with gastroesophageal reflux disease",
abstract = "In 11 children (mean age 44.2 months) with symptoms suggesting upper intestinal dysfunction (nonulcer dyspepsia), in nine children (mean age 27.3 months) with gastroesophageal reflux (GER) disease, and in seven controls (mean age 20.4 months) we investigated fasting [for 3 hr or until two migrating motor complexes (MMC) were observed] and fed (90 min) antroduodenal motility by means of perfused catheter system; furthermore, we measured both gastric emptying of a radiolabeled milk formula and fasting duodenogastric reflux during manometry by assessing bile salt concentration in gastric aspirates. No structural abnormalities of gastrointestinal tract and organic disorders were detected in the patients. In a high proportion of both groups of patients we found manometric abnormalities of interdigestive and fed motor patterns that were not seen in the controls: absence of antral phase III of MMC; significant decrease of antral and/or duodenal motor activity during fasting and/or fed periods; abnormal propagation or configuration of MMC phase III that was signficantly shorter than in controls; bursts of sustained fasting and/or fed phasic duodenal activity, frequently uncoordinated with adjacent gut segments. When compared to controls, the mean intragastric concentration of bile salts during all MMC phases and the mean 1-hr percent gastric activity of the radiolabeled milk were significantly higher in the two groups of patients. We conclude that in a high proportion of children with nonulcer dyspepsia and of children with GER disease, gastrointestinal manometry may reveal significant irregularities of antral and duodenal motility, which are associated with increased duodenogastric reflux and delayed gastric emptying.",
keywords = "bile salt concentration, gastric emptying, migrating motor complexes, nonulcer dyspepsia",
author = "S. Cucchiara and M. Bortolotti and C. Colombo and A. Boccieri and {De Stefano}, M. and G. Vitiello and A. Pagano and A. Ronchi and S. Auricchio",
year = "1991",
month = "8",
doi = "10.1007/BF01297448",
language = "English",
volume = "36",
pages = "1066--1073",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "8",

}

TY - JOUR

T1 - Abnormalities of gastrointestinal motility in children with nonulcer dyspepsia and in children with gastroesophageal reflux disease

AU - Cucchiara, S.

AU - Bortolotti, M.

AU - Colombo, C.

AU - Boccieri, A.

AU - De Stefano, M.

AU - Vitiello, G.

AU - Pagano, A.

AU - Ronchi, A.

AU - Auricchio, S.

PY - 1991/8

Y1 - 1991/8

N2 - In 11 children (mean age 44.2 months) with symptoms suggesting upper intestinal dysfunction (nonulcer dyspepsia), in nine children (mean age 27.3 months) with gastroesophageal reflux (GER) disease, and in seven controls (mean age 20.4 months) we investigated fasting [for 3 hr or until two migrating motor complexes (MMC) were observed] and fed (90 min) antroduodenal motility by means of perfused catheter system; furthermore, we measured both gastric emptying of a radiolabeled milk formula and fasting duodenogastric reflux during manometry by assessing bile salt concentration in gastric aspirates. No structural abnormalities of gastrointestinal tract and organic disorders were detected in the patients. In a high proportion of both groups of patients we found manometric abnormalities of interdigestive and fed motor patterns that were not seen in the controls: absence of antral phase III of MMC; significant decrease of antral and/or duodenal motor activity during fasting and/or fed periods; abnormal propagation or configuration of MMC phase III that was signficantly shorter than in controls; bursts of sustained fasting and/or fed phasic duodenal activity, frequently uncoordinated with adjacent gut segments. When compared to controls, the mean intragastric concentration of bile salts during all MMC phases and the mean 1-hr percent gastric activity of the radiolabeled milk were significantly higher in the two groups of patients. We conclude that in a high proportion of children with nonulcer dyspepsia and of children with GER disease, gastrointestinal manometry may reveal significant irregularities of antral and duodenal motility, which are associated with increased duodenogastric reflux and delayed gastric emptying.

AB - In 11 children (mean age 44.2 months) with symptoms suggesting upper intestinal dysfunction (nonulcer dyspepsia), in nine children (mean age 27.3 months) with gastroesophageal reflux (GER) disease, and in seven controls (mean age 20.4 months) we investigated fasting [for 3 hr or until two migrating motor complexes (MMC) were observed] and fed (90 min) antroduodenal motility by means of perfused catheter system; furthermore, we measured both gastric emptying of a radiolabeled milk formula and fasting duodenogastric reflux during manometry by assessing bile salt concentration in gastric aspirates. No structural abnormalities of gastrointestinal tract and organic disorders were detected in the patients. In a high proportion of both groups of patients we found manometric abnormalities of interdigestive and fed motor patterns that were not seen in the controls: absence of antral phase III of MMC; significant decrease of antral and/or duodenal motor activity during fasting and/or fed periods; abnormal propagation or configuration of MMC phase III that was signficantly shorter than in controls; bursts of sustained fasting and/or fed phasic duodenal activity, frequently uncoordinated with adjacent gut segments. When compared to controls, the mean intragastric concentration of bile salts during all MMC phases and the mean 1-hr percent gastric activity of the radiolabeled milk were significantly higher in the two groups of patients. We conclude that in a high proportion of children with nonulcer dyspepsia and of children with GER disease, gastrointestinal manometry may reveal significant irregularities of antral and duodenal motility, which are associated with increased duodenogastric reflux and delayed gastric emptying.

KW - bile salt concentration

KW - gastric emptying

KW - migrating motor complexes

KW - nonulcer dyspepsia

UR - http://www.scopus.com/inward/record.url?scp=0025874625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025874625&partnerID=8YFLogxK

U2 - 10.1007/BF01297448

DO - 10.1007/BF01297448

M3 - Article

C2 - 1864198

AN - SCOPUS:0025874625

VL - 36

SP - 1066

EP - 1073

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 8

ER -