Abnormalities of rCBF in cirrhotic patients are reversed by orthotopic liver transplantation

A. Cagnin, G. Pizzolato, P. Burra, M. Dam

Research output: Contribution to journalArticlepeer-review


Cirrhotic patients without signs of hepatic encephalopathy may have cognitive as well as rCBF alterations, which may depend upon neuronal damage due to the liver disease. We studied by means of SPECT and 99mTc-HMPAO as a rCBF tracer, whether the abnormalities of brain functional activity can be reversed by liver transplantation. Eigth, neurologically normal cirrhotic patients were selected. SPECT study was performed before and one year after successful liver transplantation. Before surgery, the SPECT study showed reductions of tracer uptake in the majority of cortical regions compared with normal controls. After surgery, tracer uptake, improved in all cortical regions to normal values.These results suggest that long-lasting liver transplantation normalizes brain functional activity of cirrhotic patients. Therefore longlasting liver disease does not produce irreversible neuronal damage.

Original languageEnglish
Pages (from-to)138
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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