Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases

Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Paola Stirpe & 19 others Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B. Frisoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanolu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, John Paul Taylor, Maria Francesca De Pandis, Laura Bonanni

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.

Original languageEnglish
Pages (from-to)247-268
Number of pages22
JournalJournal of Alzheimer's Disease
Volume62
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Lewy Body Disease
Electroencephalography
Cortical Synchronization
ROC Curve
Alzheimer Disease
Lewy Bodies
Wakefulness
Validation Studies
Arousal
Education
Cognitive Dysfunction
Brain

Keywords

  • Exact low resolution brain electromagnetic source tomography (eLORETA)
  • mild cognitive impairment due to Alzheimer's disease
  • mild cognitive impairment due to dementia with Lewy bodies
  • receiver operating characteristic curve
  • resting state electroencephalographic rhythms

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases. / Babiloni, Claudio; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Aarsland, Dag; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Garn, Heinrich; Fraioli, Lucia; Pievani, Michela; Frisoni, Giovanni B.; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanolu, Lutfu; Başar, Erol; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Franciotti, Raffaella; Taylor, John Paul; De Pandis, Maria Francesca; Bonanni, Laura.

In: Journal of Alzheimer's Disease, Vol. 62, No. 1, 01.01.2018, p. 247-268.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Lopez, S, Soricelli, A, Ferri, R, Pascarelli, MT, Catania, V, Nobili, F, Arnaldi, D, Famà, F, Aarsland, D, Orzi, F, Buttinelli, C, Giubilei, F, Onofrj, M, Stocchi, F, Vacca, L, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Garn, H, Fraioli, L, Pievani, M, Frisoni, GB, D'Antonio, F, De Lena, C, Güntekin, B, Hanolu, L, Başar, E, Yener, G, Emek-Savaş, DD, Triggiani, AI, Franciotti, R, Taylor, JP, De Pandis, MF & Bonanni, L 2018, 'Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases', Journal of Alzheimer's Disease, vol. 62, no. 1, pp. 247-268. https://doi.org/10.3233/JAD-170703
Babiloni, Claudio ; Del Percio, Claudio ; Lizio, Roberta ; Noce, Giuseppe ; Lopez, Susanna ; Soricelli, Andrea ; Ferri, Raffaele ; Pascarelli, Maria Teresa ; Catania, Valentina ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco ; Aarsland, Dag ; Orzi, Francesco ; Buttinelli, Carla ; Giubilei, Franco ; Onofrj, Marco ; Stocchi, Fabrizio ; Vacca, Laura ; Stirpe, Paola ; Fuhr, Peter ; Gschwandtner, Ute ; Ransmayr, Gerhard ; Garn, Heinrich ; Fraioli, Lucia ; Pievani, Michela ; Frisoni, Giovanni B. ; D'Antonio, Fabrizia ; De Lena, Carlo ; Güntekin, Bahar ; Hanolu, Lutfu ; Başar, Erol ; Yener, Görsev ; Emek-Savaş, Derya Durusu ; Triggiani, Antonio Ivano ; Franciotti, Raffaella ; Taylor, John Paul ; De Pandis, Maria Francesca ; Bonanni, Laura. / Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases. In: Journal of Alzheimer's Disease. 2018 ; Vol. 62, No. 1. pp. 247-268.
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AU - Del Percio, Claudio

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Soricelli, Andrea

AU - Ferri, Raffaele

AU - Pascarelli, Maria Teresa

AU - Catania, Valentina

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Aarsland, Dag

AU - Orzi, Francesco

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AU - Giubilei, Franco

AU - Onofrj, Marco

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Stirpe, Paola

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Garn, Heinrich

AU - Fraioli, Lucia

AU - Pievani, Michela

AU - Frisoni, Giovanni B.

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanolu, Lutfu

AU - Başar, Erol

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Triggiani, Antonio Ivano

AU - Franciotti, Raffaella

AU - Taylor, John Paul

AU - De Pandis, Maria Francesca

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KW - mild cognitive impairment due to Alzheimer's disease

KW - mild cognitive impairment due to dementia with Lewy bodies

KW - receiver operating characteristic curve

KW - resting state electroencephalographic rhythms

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