Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2716-2731 |
| Number of pages | 16 |
| Journal | Clin. Neurophysiol. |
| Volume | 131 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2020 |
Keywords
- Exact low-resolution brain electromagnetic source tomography (eLORETA)
- Mild cognitive impairment (MCI)
- Prodromal and overt dementia with Lewy bodies (DLB)
- Rapid eye movement sleep behavior disorders (RBD)
- Resting state electroencephalographic (EEG) rhythms
- Visual hallucinations
- aged
- alpha rhythm
- Alzheimer disease
- Article
- beta rhythm
- clinical feature
- cognitive defect
- controlled study
- cross validation
- delta rhythm
- diffuse Lewy body disease
- electroencephalogram
- female
- gamma rhythm
- human
- major clinical study
- male
- mild cognitive impairment
- Mini Mental State Examination
- observational study
- occipital cortex
- parasomnia
- parietal cortex
- preliminary data
- priority journal
- prodromal symptom
- REM sleep
- resting state network
- retrospective study
- spectroscopy
- theta rhythm
- Unified Parkinson Disease Rating Scale
- visual hallucination
Fingerprint Dive into the research topics of 'Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms'. Together they form a unique fingerprint.
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms. / Pascarelli, M.T.; Del Percio, C.; De Pandis, M.F.; Ferri, R.; Lizio, R.; Noce, G.; Lopez, S.; Rizzo, M.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Famà, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Salvetti, M.; Cipollini, V.; Franciotti, R.; Onofri, M.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Aarsland, D.; Parnetti, L.; Farotti, L.; Marizzoni, M.; D'Antonio, F.; De Lena, C.; Güntekin, B.; Hanoğlu, L.; Yener, G.; Emek-Savaş, D.D.; Ivano Triggiani, A.; Paul Taylor, J.; McKeith, I.; Stocchi, F.; Vacca, L.; Hampel, H.; Frisoni, G.B.; Bonanni, L.; Babiloni, C.
In: Clin. Neurophysiol., Vol. 131, No. 11, 2020, p. 2716-2731.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies:
T2 - Relation to clinical symptoms
AU - Pascarelli, M.T.
AU - Del Percio, C.
AU - De Pandis, M.F.
AU - Ferri, R.
AU - Lizio, R.
AU - Noce, G.
AU - Lopez, S.
AU - Rizzo, M.
AU - Soricelli, A.
AU - Nobili, F.
AU - Arnaldi, D.
AU - Famà, F.
AU - Orzi, F.
AU - Buttinelli, C.
AU - Giubilei, F.
AU - Salvetti, M.
AU - Cipollini, V.
AU - Franciotti, R.
AU - Onofri, M.
AU - Fuhr, P.
AU - Gschwandtner, U.
AU - Ransmayr, G.
AU - Aarsland, D.
AU - Parnetti, L.
AU - Farotti, L.
AU - Marizzoni, M.
AU - D'Antonio, F.
AU - De Lena, C.
AU - Güntekin, B.
AU - Hanoğlu, L.
AU - Yener, G.
AU - Emek-Savaş, D.D.
AU - Ivano Triggiani, A.
AU - Paul Taylor, J.
AU - McKeith, I.
AU - Stocchi, F.
AU - Vacca, L.
AU - Hampel, H.
AU - Frisoni, G.B.
AU - Bonanni, L.
AU - Babiloni, C.
N1 - Export Date: 22 February 2021 CODEN: CNEUF Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer”, P. le A. Moro 5, Italy; email: claudio.babiloni@uniroma1.it Funding details: Horizon 2020 Framework Programme, H2020 Funding text 1: The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Bodies. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. In this study, the electroencephalographic data analysis was partially supported by the funds of “Ricerca Corrente” attributed by Italian Ministry of Health to the Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) SDN of Naples, the IRCCS OASI of Troina, and the IRCCS San Raffaele Pisana of Rome. The research activities of the Unit of Sapienza University of Rome were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title “BBDiag” (http://bbdiag-itn-etn.eu) and the H2020 - TWINN-2015 project with the short title “SynaNet” (https://www.synanet2020.com). References: Aitta-Aho, T., Hay, Y.A., Phillips, B.U., Saksida, L.M., Bussey, T.J., Paulsen, O., Apergis-Schoute, J., Basal forebrain and brainstem cholinergic neurons differentially impact amygdala circuits and learning-related behavior (2018) Curr Biol, 28 (16), pp. 2557-2569.e4; Andersson, M., Hansson, O., Minthon, L., Rosén, I., Londos, E., Electroencephalogram variability in dementia with lewy bodies, Alzheimer's disease and controls (2008) Dement Geriatr Cogn Disord, 26 (3), pp. 284-290; Aoki, Y., Kazui, H., Pascal-Marqui, R.D., Ishii, R., Yoshiyama, K., Kanemoto, H., EEG resting-state networks in dementia with lewy bodies associated with clinical symptoms (2019) Neuropsychobiology, 77 (4), pp. 206-218; Azzopardi, E., Louttit, A.G., DeOliveira, C., Laviolette, S.R., Schmid, S., The role of cholinergic midbrain neurons in startle and prepulse inhibition (2018) J Neurosci, 38 (41), pp. 8798-8808; Babiloni, C., Barry, R.J., Başar, E., Blinowska, K.J., Cichocki, A., Drinkenburg, W.H.I.M., International Federation of Clinical Neurophysiology (IFCN) - EEG research workgroup: recommendations on frequency and topographic analysis of resting state EEG rhythms. Part 1: Applications in clinical research studies (2020) Clin Neurophysiol, 131 (1), pp. 285-307; Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Cordone, S., Lopez, S., Abnormalities of cortical neural synchronization mechanisms in subjects with mild cognitive impairment due to Alzheimer's and Parkinson's Diseases: an EEG study (2017) J Alzheimers Dis, 59 (1), pp. 339-358; Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Cordone, S., Lopez, S., Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study (2017) Neurobiol Aging, 55, pp. 143-158; Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A., Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases (2018) Clin Neurophysiol, 129 (4), pp. 766-782; Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A., Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study (2018) Neurobiol Aging, 65, pp. 18-40; Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A., Abnormalities of resting state cortical EEG rhythms in subjects with mild cognitive impairment due to Alzheimer's and Lewy body diseases (2018) J Alzheimers Dis, 62 (1), pp. 247-268; Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A., Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms (2019) Neurobiol Aging, 73, pp. 9-20; Babiloni, C., Pascarelli, M.T., Lizio, R., Noce, G., Lopez, S., Rizzo, M., Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study (2020) Neurobiol Aging; Bentley, P., Driver, J., Dolan, R.J., Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health (2008) Brain, 131, pp. 409-424; Bodenmann, S., Rusterholz, T., Dürr, R., Stoll, C., Bachmann, V., Geissler, E., The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men (2009) J Neurosci, 29 (35), pp. 10855-10862; Bonanni, L., Perfetti, B., Bifolchetti, S., Taylor, J.P., Franciotti, R., Parnetti, L., Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies (2015) Neurobiol Aging, 36 (1), pp. 434-445; Bonanni, L., Thomas, A., Tiraboschi, P., Perfetti, B., Varanese, S., Onofrj, M., EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up (2008) Brain, 131, pp. 690-705; Bosboom, J.L., Stoffers, D., Stam, C.J., van Dijk, B.W., Verbunt, J., Berendse, H.W., Resting state oscillatory brain dynamics in Parkinson's disease: an MEG study (2006) Clin Neurophysiol, 117, pp. 2521-2531; Bosboom, J.L., Stoffers, D., Wolters, E.C., Stam, C.J., Berendse, H.W., MEG resting state functional connectivity in Parkinson's disease related dementia (2009) J Neural Transm, 116, pp. 193-202; Brown, L.M., Schinka, J.A., Development and initial validation of a 15-item informant version of the Geriatric Depression Scale (2005) Int J Geriatr Psychiatry, 20, pp. 911-918; Cash, R., Dennis, T., L'Heureux, R., Raisman, R., Javoy-Agid, F., Scatton, B., Parkinson's disease and dementia: norepinephrine and dopamine in locus ceruleus (1987) Neurology, 37, p. 42; Caviness, J.N., Beach, T.G., Hentz, J.G., Shill, H.A., Driver-Dunckley, E.D., Adler, C.H., Association between pathology and electroencephalographic activity in Parkinson's disease (2018) Clin EEG Neurosci, 49 (5), pp. 321-327; Caviness, J.N., Lue, L.F., Hentz, J.G., Schmitz, C.T., Adler, C.H., Shill, H.A., Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease (2016) Mov Disord, 31 (7), pp. 1012-1019; Chapotot, F., Pigeau, R., Canini, F., Bourdon, L., Buguet, A., Distinctive effects of modafinil and d-amphetamine on the homeostatic and circadian modulation of the human waking EEG (2003) Psychopharmacology, 166 (2), pp. 127-138; Cummings, J.L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D.A., Gornbein, J., The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia (1994) Neurology, 44 (12), pp. 2308-2314; Dauwan, M., Linszen, M.M.J., Lemstra, A.W., Scheltens, P., Stam, C.J., Sommer, I.E., EEG-based neurophysiological indicators of hallucinations in Alzheimer's disease: comparison with dementia with Lewy bodies (2018) Neurobiol Aging, 67, pp. 75-83; Del Tredici, K., Braak, H., Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia (2013) J Neurol Neurosurg Psychiatry, 84 (7), pp. 774-783; DeLong, E.R., DeLong, D.M., Clarke-Pearson, D.L., Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach (1988) Biometrics, 44 (3), pp. 837-845; Diaconescu, A.O., Kovacevic, N., McIntosh, A.R., Modality-independent processes in cued motor preparation revealed by cortical potentials (2008) Neuroimage, 42 (3), pp. 1255-1265; Donaghy, P.C., McKeith, I.G., The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis (2014) Alzheimers Res Ther, 6 (4), p. 46; Donaghy, P.C., Taylor, J.P., O'Brien, J.T., Barnett, N., Olsen, K., Colloby, S.J., Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies (2018) Psychol Med, 48 (14), pp. 2384-2390; Dubois, B., Slachevsky, A., Litvan, I., Pillon, B., The FAB: a Frontal Assessment Battery at bedside (2000) Neurology, 55 (11), pp. 1621-1626; Dugger, B.N., Murray, M.E., Boeve, B.F., Parisi, J.E., Benarroch, E.E., Ferman, T.J., Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder (2012) Neuropathol Appl Neurobiol; Fahn, S., Marsden, C.D., Calne, D.B., Goldstein, M., (1987), pp. 293-304. , editors. Recent developments in Parkinson's disease, vol. 2. Florham Park, NJ. Macmillan Health Care Information p. 153–63; Fantini, M.L., Gagnon, J.F., Petit, D., Rompre, S., Decary, A., Carrier, J., Slowing of electroencephalogram in rapid eye movement sleep behavior disorder (2003) Ann Neurol, 53, pp. 774-780; Fünfgeld, E.W., Computerised brain electrical activity findings of parkinson patients suffering from hyperkinetic side effects (hypersensitive dopamine syndrome) and a review of possible sources (1995) J Neural Transm Suppl, 46, pp. 351-365; Halder, T., Talwar, S., Jaiswal, A.K., Banerjee, A., Quantitative evaluation in estimating sources underlying brain oscillations using current source density methods and beamformer approaches (2019) eNeuro, 6 (4). , ENEURO.0170-19.201; Hughes, S.W., Crunelli, V., Thalamic mechanisms of EEG alpha rhythms and their pathological implications (2005) Neuroscientist, 11, pp. 357-372; Inoue, Y., Sasai, T., Hirata, K., Electroencephalographic finding in idiopathic REM sleep behavior disorder (2015) Neuropsychobiology, 71 (1), pp. 25-33; Iranzo, A., Isetta, V., Molinuevo, J.L., Serradell, M., Navajas, D., Farre, R., Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder (2010) Sleep Med, 11, pp. 534-539; Jackson, C.E., Snyder, P.J., Khachaturian, Z.S., Brookmeyer, R., Johnson, E., Ziegler-Graham, K., Electroencephalography and event-related potentials as biomarkers of mild cognitive impairment and mild Alzheimer's disease (2008) Alzheimers Dement, 4, pp. S137-S143; James, L.M., Iannone, R., Palcza, J., Renger, J.J., Calder, N., Cerchio, K., Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers (2011) Psychopharmacology, 215, pp. 643-653; Janzen, J., van't Ent, D., Lemstra, A.W., Berendse, H.W., Barkhof, F., Foncke, E.M., The pedunculopontine nucleus is related to visual hallucinations in Parkinson's disease: preliminary results of a voxel-based morphometry study (2012) J Neurol, 259 (1), pp. 147-154; Jia, H., Yu, D., Attenuated long-range temporal correlations of electrocortical oscillations in patients with autism spectrum disorder (2019) Dev Cogn Neurosci, 30 (39), p. 100687; Jones, B.E., Harper, S.T., Halaris, A.E., Effects of locus coeruleus lesions upon cerebral monoamine content, sleep-wakefulness states and the response to amphetamine in the cat (1977) Brain Res, 124 (3), pp. 473-496; Kai, T., Asai, Y., Sakuma, K., Koeda, T., Nakashima, K., Quantitative electroencephalogram analysis in dementia with Lewy bodies and Alzheimer's disease (2005) J Neurol Sci, 237 (1-2), pp. 89-95; Kamei, S., Morita, A., Serizawa, K., Mizutani, T., Hirayanagi, K., Quantitative EEG analysis of executive dysfunction in Parkinson disease (2010) J Clin Neurophysiol, 27, pp. 193-197; Klimesch, W., Doppelmayr, M., Russegger, H., Pachinger, T., Schwaiger, J., Induced alpha band power changes in the human EEG and attention (1998) Neurosci Lett, 244 (2), pp. 73-76; Klimesch, W., Doppelmayr, M., Schimke, H., Pachinger, T., Alpha frequency, reaction time, and the speed of processing information (1996) J Clin Neurophysiol, 13, pp. 511-518; Klimesch, W., EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis (1999) Brain Res Brain Res Rev, 29, pp. 169-195; Kovacevic, N., McIntosh, A.R., Groupwise independent component decomposition of EEG data and partial least square analysis (2007) Neuroimage, 35 (3), pp. 1103-1112; Lehmann, D., Ozaki, H., Pal, I., EEG alpha map series: brain micro-states by space-oriented adaptive segmentation (1987) Electroenceph Clin Neurophysiol, 67, pp. 271-288; Liu, Q., Ganzetti, M., Wenderoth, N., Mantini, D., Detecting large-scale brain networks using EEG: impact of electrode density, head modeling and source localization (2018) Front Neuroinform, 12, p. 4; Lörincz, M.L., Crunelli, V., Hughes, S.W., Cellular dynamics of cholinergically induced alpha (8–13Hz) rythms in sensory thalamic nuclei in vitro (2008) J Neurosci, 28, pp. 660-671; Lorincz, M.L., Kékesi, K.A., Juhász, G., Crunelli, V., Hughes, Temporal framing of thalamic relay-mode firing by phasic inhibition during the alpha rythm (2009) Neuron, 63, pp. 683-696; Marino, M., Liu, Q., Brem, S., Wenderoth, N., Mantini, D., Automated detection and labeling of high-density EEG electrodes from structural MR images (2016) J Neural Eng, 13 (5), p. 056003; Massicotte-Marquez, J., Carrier, J., Decary, A., Mathieu, A., Vendette, M., Petit, D., Slow-wave sleep and delta power in rapid eye movement sleep behavior disorder (2005) Ann Neurol, 57, pp. 277-282; Massironi, G., Galluzzi, S., Frisoni, G.B., Drug treatment of REM sleep behavior disorders in dementia with Lewy bodies (2003) Int Psychogeriatr, 15 (4), pp. 377-383; McKeith, I.G., Boeve, B.F., Dickson, D.W., Halliday, G., Taylor, J.P., Weintraub, D., Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium (2017) Neurology, 89 (1), pp. 88-100; McKeith, I.G., Dickson, D.W., Lowe, J., Emre, M., O'Brien, J.T., Feldman, H., Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium (2005) Neurology, 65, pp. 1863-1872; McKeith, I.G., Galasko, D., Kosaka, K., Perry, E.K., Dickson, D.W., Hansen, L.A., Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop (1996) Neurology, 47 (5), pp. 1113-1124; McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA work group under the auspices of department of health and human services task force on alzheimer's disease (1984) Neurology, 34, pp. 939-944; Melgari, J.M., Curcio, G., Mastrolilli, F., Salomone, G., Trotta, L., Tombini, M., Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients (2014) Front Aging Neurosci, 6, p. 302; Michel, C.M., Koenig, T., EEG microstates as a tool for studying the temporal dynamics of whole-brain neuronal networks: a review (2018) Neuroimage, 180, pp. 577-593; Michel, C.M., Lantz, G., Spinelli, L., de Peralta, R.G., Landis, T., Seeck, M., 128-Channel EEG source imaging in epilepsy: clinical yield and localization precision (2004) J Clin Neurophysiol, 21 (2), pp. 71-83; Moretti, D.V., Babiloni, C., Binetti, G., Cassetta, E., Dal Forno, G., Ferreric, F., Individual analysis of EEG frequency and band power in mild Alzheimer's disease (2004) Clin Neurophysiol, 115 (2), pp. 299-308; Moretti, D.V., Babiloni, F., Carducci, F., Cincotti, F., Remondini, E., Rossini, P.M., Computerized processing of EEG-EOG-EMG artifacts for multicentirc studies in EEG oscillations and event-related potentials (2003) Int J Pshycophysiol, 47 (3), pp. 199-216; Pascual-Marqui, R.D., Discrete, 3D distributed, linear imaging methods of electric neuronal activity. Part 1: exact, zero error localization. 2007 arXiv:0710.3341 [math-ph] Available at: [accessed November 19, 2015]; Pfurtscheller, G., Lopes da Silva, F.H., Event-related EEG/MEG synchronization and desynchronization: basic principles (1999) Clin Neurophysiol, 110, pp. 1842-1857; Pugnetti, L., Baglio, F., Farina, E., Alberoni, M., Calabrese, E., Gambini, A., EEG evidence of posterior cortical disconnection in PD and related dementias (2010) Int J Neurosci, 120, pp. 88-98; Rodrigues Brazete, J., Montplaisir, J., Petit, D., Postuma, R.B., Bertrand, J.A., Genier Marchand, D., Electroencephalogram slowing in rapid eye movement sleep behavior disorder is associated with mild cognitive impairment (2013) Sleep Med, 14, pp. 1059-1063; Saletu, M., Anderer, P., Saletu-Zyhlarz, G.M., Mandl, M., Arnold, O., Zeitlhofer, J., EEG-tomographic studies with LORETA on vigilance differences between narcolepsy patients and controls and subsequent double-blind, placebo-controlled studies with modafinil (2004) J Neurol, 251 (11), pp. 1354-1363; Saletu, M., Anderer, P., Semlitsch, H.V., Saletu-Zyhlarz, G.M., Mandl, M., Zeitlhofer, J., Low-resolution brain electromagnetic tomography (LORETA) identifies brain regions linked to psychometric performance under modafinil in narcolepsy (2007) Psychiatry Res, 154 (1), pp. 69-84; Samogin, J., Liu, Q., Marino, M., Wenderoth, N., Mantini, D., Shared and connection-specific intrinsic interactions in the default mode network (2019) Neuroimage, 200, pp. 474-481; Serizawa, K., Kamei, S., Morita, A., Hara, M., Mizutani, T., Yoshihashi, H., Comparison of quantitative EEGs between Parkinson disease and age-adjusted normal controls (2008) J Clin Neurophysiol, 25, pp. 361-366; Steriade, M., Llinás, R.R., The functional states of the thalamus and the associated neuronal interplay (1988) Physiol Rev, 68 (3), pp. 649-742; Stylianou, M., Murphy, N., Peraza, L.R., Graziadio, S., Cromarty, R., Killen, A., Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis (2018) Clin Neurophysiol, 129 (6), pp. 1209-1220; Vermeiren, Y., Deyn, D., Targeting the norepinephrinergic system in Parkinson's disease and related disorders: the locus coeruleus story (2017) Neurochem Int, 102, pp. 22-32; Walker, M.P., Ayre, G.A., Cummings, J.L., Wesnes, K., McKeith, I.G., O'Brien, J.T., The clinician assessment of fluctuation and the one day fluctuation assessment scale. Two methods to assess fluctuating confusion in dementia (2000) Br J Psychiatry, 177, pp. 252-256; Walker, M.P., Ayre, G.A., Perry, E.K., Wesnes, K., McKeith, I.G., Tovee, M., Quantification and characterization of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease (2000) Dement Geriatr Cogn Disord, 11 (6), pp. 327-335; Weisman, D., Cho, M., Taylor, C., Adame, A., Thal, L.J., Hansen, L.A., In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution (2007) Neurology, 69 (4), pp. 356-359; Yeomans, J.S., Muscarinic receptors in brain stem and mesopontine cholinergic arousal functions (2012) Handb Exp Pharmacol, 208, pp. 243-259; Zweig, R.M., Cardillo, J.E., Cohen, M., Giere, S., Hedreen, J.C., The locus ceruleus and dementia in Parkinson's disease (1993) Neurology, 43, p. 986
PY - 2020
Y1 - 2020
N2 - Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p <0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p <0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p <0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies. © 2020 International Federation of Clinical Neurophysiology
AB - Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p <0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p <0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p <0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies. © 2020 International Federation of Clinical Neurophysiology
KW - Exact low-resolution brain electromagnetic source tomography (eLORETA)
KW - Mild cognitive impairment (MCI)
KW - Prodromal and overt dementia with Lewy bodies (DLB)
KW - Rapid eye movement sleep behavior disorders (RBD)
KW - Resting state electroencephalographic (EEG) rhythms
KW - Visual hallucinations
KW - aged
KW - alpha rhythm
KW - Alzheimer disease
KW - Article
KW - beta rhythm
KW - clinical feature
KW - cognitive defect
KW - controlled study
KW - cross validation
KW - delta rhythm
KW - diffuse Lewy body disease
KW - electroencephalogram
KW - female
KW - gamma rhythm
KW - human
KW - major clinical study
KW - male
KW - mild cognitive impairment
KW - Mini Mental State Examination
KW - observational study
KW - occipital cortex
KW - parasomnia
KW - parietal cortex
KW - preliminary data
KW - priority journal
KW - prodromal symptom
KW - REM sleep
KW - resting state network
KW - retrospective study
KW - spectroscopy
KW - theta rhythm
KW - Unified Parkinson Disease Rating Scale
KW - visual hallucination
U2 - 10.1016/j.clinph.2020.09.004
DO - 10.1016/j.clinph.2020.09.004
M3 - Article
VL - 131
SP - 2716
EP - 2731
JO - Clin. Neurophysiol.
JF - Clin. Neurophysiol.
SN - 1388-2457
IS - 11
ER -