Abstract
Original language | English |
---|---|
Pages (from-to) | 2716-2731 |
Number of pages | 16 |
Journal | Clin. Neurophysiol. |
Volume | 131 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Exact low-resolution brain electromagnetic source tomography (eLORETA)
- Mild cognitive impairment (MCI)
- Prodromal and overt dementia with Lewy bodies (DLB)
- Rapid eye movement sleep behavior disorders (RBD)
- Resting state electroencephalographic (EEG) rhythms
- Visual hallucinations
- aged
- alpha rhythm
- Alzheimer disease
- Article
- beta rhythm
- clinical feature
- cognitive defect
- controlled study
- cross validation
- delta rhythm
- diffuse Lewy body disease
- electroencephalogram
- female
- gamma rhythm
- human
- major clinical study
- male
- mild cognitive impairment
- Mini Mental State Examination
- observational study
- occipital cortex
- parasomnia
- parietal cortex
- preliminary data
- priority journal
- prodromal symptom
- REM sleep
- resting state network
- retrospective study
- spectroscopy
- theta rhythm
- Unified Parkinson Disease Rating Scale
- visual hallucination
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Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms. / Pascarelli, M.T.; Del Percio, C.; De Pandis, M.F.; Ferri, R.; Lizio, R.; Noce, G.; Lopez, S.; Rizzo, M.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Famà, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Salvetti, M.; Cipollini, V.; Franciotti, R.; Onofri, M.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Aarsland, D.; Parnetti, L.; Farotti, L.; Marizzoni, M.; D'Antonio, F.; De Lena, C.; Güntekin, B.; Hanoğlu, L.; Yener, G.; Emek-Savaş, D.D.; Ivano Triggiani, A.; Paul Taylor, J.; McKeith, I.; Stocchi, F.; Vacca, L.; Hampel, H.; Frisoni, G.B.; Bonanni, L.; Babiloni, C.
In: Clin. Neurophysiol., Vol. 131, No. 11, 2020, p. 2716-2731.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies:
T2 - Relation to clinical symptoms
AU - Pascarelli, M.T.
AU - Del Percio, C.
AU - De Pandis, M.F.
AU - Ferri, R.
AU - Lizio, R.
AU - Noce, G.
AU - Lopez, S.
AU - Rizzo, M.
AU - Soricelli, A.
AU - Nobili, F.
AU - Arnaldi, D.
AU - Famà, F.
AU - Orzi, F.
AU - Buttinelli, C.
AU - Giubilei, F.
AU - Salvetti, M.
AU - Cipollini, V.
AU - Franciotti, R.
AU - Onofri, M.
AU - Fuhr, P.
AU - Gschwandtner, U.
AU - Ransmayr, G.
AU - Aarsland, D.
AU - Parnetti, L.
AU - Farotti, L.
AU - Marizzoni, M.
AU - D'Antonio, F.
AU - De Lena, C.
AU - Güntekin, B.
AU - Hanoğlu, L.
AU - Yener, G.
AU - Emek-Savaş, D.D.
AU - Ivano Triggiani, A.
AU - Paul Taylor, J.
AU - McKeith, I.
AU - Stocchi, F.
AU - Vacca, L.
AU - Hampel, H.
AU - Frisoni, G.B.
AU - Bonanni, L.
AU - Babiloni, C.
N1 - Export Date: 22 February 2021 CODEN: CNEUF Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer”, P. le A. Moro 5, Italy; email: claudio.babiloni@uniroma1.it Funding details: Horizon 2020 Framework Programme, H2020 Funding text 1: The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Bodies. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. In this study, the electroencephalographic data analysis was partially supported by the funds of “Ricerca Corrente” attributed by Italian Ministry of Health to the Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) SDN of Naples, the IRCCS OASI of Troina, and the IRCCS San Raffaele Pisana of Rome. The research activities of the Unit of Sapienza University of Rome were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title “BBDiag” (http://bbdiag-itn-etn.eu) and the H2020 - TWINN-2015 project with the short title “SynaNet” (https://www.synanet2020.com). 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PY - 2020
Y1 - 2020
N2 - Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p <0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p <0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p <0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies. © 2020 International Federation of Clinical Neurophysiology
AB - Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p <0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p <0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p <0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies. © 2020 International Federation of Clinical Neurophysiology
KW - Exact low-resolution brain electromagnetic source tomography (eLORETA)
KW - Mild cognitive impairment (MCI)
KW - Prodromal and overt dementia with Lewy bodies (DLB)
KW - Rapid eye movement sleep behavior disorders (RBD)
KW - Resting state electroencephalographic (EEG) rhythms
KW - Visual hallucinations
KW - aged
KW - alpha rhythm
KW - Alzheimer disease
KW - Article
KW - beta rhythm
KW - clinical feature
KW - cognitive defect
KW - controlled study
KW - cross validation
KW - delta rhythm
KW - diffuse Lewy body disease
KW - electroencephalogram
KW - female
KW - gamma rhythm
KW - human
KW - major clinical study
KW - male
KW - mild cognitive impairment
KW - Mini Mental State Examination
KW - observational study
KW - occipital cortex
KW - parasomnia
KW - parietal cortex
KW - preliminary data
KW - priority journal
KW - prodromal symptom
KW - REM sleep
KW - resting state network
KW - retrospective study
KW - spectroscopy
KW - theta rhythm
KW - Unified Parkinson Disease Rating Scale
KW - visual hallucination
U2 - 10.1016/j.clinph.2020.09.004
DO - 10.1016/j.clinph.2020.09.004
M3 - Article
VL - 131
SP - 2716
EP - 2731
JO - Clin. Neurophysiol.
JF - Clin. Neurophysiol.
SN - 1388-2457
IS - 11
ER -