Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

C. Babiloni, C. Del Percio, R. Lizio, G. Noce, S. Lopez, A. Soricelli, R. Ferri, F. Nobili, D. Arnaldi, F. Famà, D. Aarsland, F. Orzi, C. Buttinelli, F. Giubilei, M. Onofrj, F. Stocchi, P. Stirpe, P. Fuhr, U. Gschwandtner, G. Ransmayr & 17 others H. Garn, L. Fraioli, M. Pievani, G.B. Frisoni, F. D'Antonio, C. De Lena, B. Güntekin, L. Hanoğlu, E. Başar, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, R. Franciotti, J.P. Taylor, L. Vacca, M.F. De Pandis, L. Bonanni

Research output: Contribution to journalArticle

Abstract

Previous evidence showed abnormal posterior sources of resting-state delta (0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. © 2017 Elsevier Inc.
Original languageEnglish
Pages (from-to)18-40
Number of pages23
JournalNeurobiology of Aging
Volume65
DOIs
Publication statusPublished - 2018

Fingerprint

Lewy Body Disease
Dementia
Electroencephalography

Keywords

  • donepezil
  • galantamine
  • rivastigmine
  • aged
  • alpha rhythm
  • Alzheimer disease
  • Article
  • beta rhythm
  • cognition
  • controlled study
  • correlational study
  • delta rhythm
  • diffuse Lewy body disease
  • disease association
  • electroencephalogram
  • female
  • functional connectivity
  • gamma rhythm
  • human
  • interhemispheric transfer
  • low resolution brain electromagnetic tomography
  • major clinical study
  • male
  • Mini Mental State Examination
  • neurophysiology
  • Parkinson disease
  • priority journal
  • resting state network
  • retrospective study
  • theta rhythm
  • brain cortex
  • complication
  • cortical synchronization
  • dementia
  • diagnostic imaging
  • electroencephalography
  • pathophysiology
  • physiology
  • psychology
  • rest
  • Aged
  • Alzheimer Disease
  • Cerebral Cortex
  • Cognition
  • Cortical Synchronization
  • Dementia
  • Electroencephalography
  • Female
  • Humans
  • Lewy Body Disease
  • Male
  • Rest

Cite this

Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study. / Babiloni, C.; Del Percio, C.; Lizio, R.; Noce, G.; Lopez, S.; Soricelli, A.; Ferri, R.; Nobili, F.; Arnaldi, D.; Famà, F.; Aarsland, D.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Onofrj, M.; Stocchi, F.; Stirpe, P.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Garn, H.; Fraioli, L.; Pievani, M.; Frisoni, G.B.; D'Antonio, F.; De Lena, C.; Güntekin, B.; Hanoğlu, L.; Başar, E.; Yener, G.; Emek-Savaş, D.D.; Triggiani, A.I.; Franciotti, R.; Taylor, J.P.; Vacca, L.; De Pandis, M.F.; Bonanni, L.

In: Neurobiology of Aging, Vol. 65, 2018, p. 18-40.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Lopez, S, Soricelli, A, Ferri, R, Nobili, F, Arnaldi, D, Famà, F, Aarsland, D, Orzi, F, Buttinelli, C, Giubilei, F, Onofrj, M, Stocchi, F, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Garn, H, Fraioli, L, Pievani, M, Frisoni, GB, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Başar, E, Yener, G, Emek-Savaş, DD, Triggiani, AI, Franciotti, R, Taylor, JP, Vacca, L, De Pandis, MF & Bonanni, L 2018, 'Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study', Neurobiology of Aging, vol. 65, pp. 18-40. https://doi.org/10.1016/j.neurobiolaging.2017.12.023
Babiloni, C. ; Del Percio, C. ; Lizio, R. ; Noce, G. ; Lopez, S. ; Soricelli, A. ; Ferri, R. ; Nobili, F. ; Arnaldi, D. ; Famà, F. ; Aarsland, D. ; Orzi, F. ; Buttinelli, C. ; Giubilei, F. ; Onofrj, M. ; Stocchi, F. ; Stirpe, P. ; Fuhr, P. ; Gschwandtner, U. ; Ransmayr, G. ; Garn, H. ; Fraioli, L. ; Pievani, M. ; Frisoni, G.B. ; D'Antonio, F. ; De Lena, C. ; Güntekin, B. ; Hanoğlu, L. ; Başar, E. ; Yener, G. ; Emek-Savaş, D.D. ; Triggiani, A.I. ; Franciotti, R. ; Taylor, J.P. ; Vacca, L. ; De Pandis, M.F. ; Bonanni, L. / Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study. In: Neurobiology of Aging. 2018 ; Vol. 65. pp. 18-40.
@article{b28389cbd7104e7e96fa4c9b7fcc41c8,
title = "Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study",
abstract = "Previous evidence showed abnormal posterior sources of resting-state delta (0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. {\circledC} 2017 Elsevier Inc.",
keywords = "donepezil, galantamine, rivastigmine, aged, alpha rhythm, Alzheimer disease, Article, beta rhythm, cognition, controlled study, correlational study, delta rhythm, diffuse Lewy body disease, disease association, electroencephalogram, female, functional connectivity, gamma rhythm, human, interhemispheric transfer, low resolution brain electromagnetic tomography, major clinical study, male, Mini Mental State Examination, neurophysiology, Parkinson disease, priority journal, resting state network, retrospective study, theta rhythm, brain cortex, complication, cortical synchronization, dementia, diagnostic imaging, electroencephalography, pathophysiology, physiology, psychology, rest, Aged, Alzheimer Disease, Cerebral Cortex, Cognition, Cortical Synchronization, Dementia, Electroencephalography, Female, Humans, Lewy Body Disease, Male, Rest",
author = "C. Babiloni and {Del Percio}, C. and R. Lizio and G. Noce and S. Lopez and A. Soricelli and R. Ferri and F. Nobili and D. Arnaldi and F. Fam{\`a} and D. Aarsland and F. Orzi and C. Buttinelli and F. Giubilei and M. Onofrj and F. Stocchi and P. Stirpe and P. Fuhr and U. Gschwandtner and G. Ransmayr and H. Garn and L. Fraioli and M. Pievani and G.B. Frisoni and F. D'Antonio and {De Lena}, C. and B. G{\"u}ntekin and L. Hanoğlu and E. Başar and G. Yener and D.D. Emek-Savaş and A.I. Triggiani and R. Franciotti and J.P. Taylor and L. Vacca and {De Pandis}, M.F. and L. Bonanni",
note = "Cited By :2 Export Date: 30 January 2019 CODEN: NEAGD Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology, “V. Erspamer” University of Rome, “La Sapienza” P. le A. Moro 5, 00185, Italy; email: claudio.babiloni@uniroma1.it",
year = "2018",
doi = "10.1016/j.neurobiolaging.2017.12.023",
language = "English",
volume = "65",
pages = "18--40",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

AU - Babiloni, C.

AU - Del Percio, C.

AU - Lizio, R.

AU - Noce, G.

AU - Lopez, S.

AU - Soricelli, A.

AU - Ferri, R.

AU - Nobili, F.

AU - Arnaldi, D.

AU - Famà, F.

AU - Aarsland, D.

AU - Orzi, F.

AU - Buttinelli, C.

AU - Giubilei, F.

AU - Onofrj, M.

AU - Stocchi, F.

AU - Stirpe, P.

AU - Fuhr, P.

AU - Gschwandtner, U.

AU - Ransmayr, G.

AU - Garn, H.

AU - Fraioli, L.

AU - Pievani, M.

AU - Frisoni, G.B.

AU - D'Antonio, F.

AU - De Lena, C.

AU - Güntekin, B.

AU - Hanoğlu, L.

AU - Başar, E.

AU - Yener, G.

AU - Emek-Savaş, D.D.

AU - Triggiani, A.I.

AU - Franciotti, R.

AU - Taylor, J.P.

AU - Vacca, L.

AU - De Pandis, M.F.

AU - Bonanni, L.

N1 - Cited By :2 Export Date: 30 January 2019 CODEN: NEAGD Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology, “V. Erspamer” University of Rome, “La Sapienza” P. le A. Moro 5, 00185, Italy; email: claudio.babiloni@uniroma1.it

PY - 2018

Y1 - 2018

N2 - Previous evidence showed abnormal posterior sources of resting-state delta (0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. © 2017 Elsevier Inc.

AB - Previous evidence showed abnormal posterior sources of resting-state delta (0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. © 2017 Elsevier Inc.

KW - donepezil

KW - galantamine

KW - rivastigmine

KW - aged

KW - alpha rhythm

KW - Alzheimer disease

KW - Article

KW - beta rhythm

KW - cognition

KW - controlled study

KW - correlational study

KW - delta rhythm

KW - diffuse Lewy body disease

KW - disease association

KW - electroencephalogram

KW - female

KW - functional connectivity

KW - gamma rhythm

KW - human

KW - interhemispheric transfer

KW - low resolution brain electromagnetic tomography

KW - major clinical study

KW - male

KW - Mini Mental State Examination

KW - neurophysiology

KW - Parkinson disease

KW - priority journal

KW - resting state network

KW - retrospective study

KW - theta rhythm

KW - brain cortex

KW - complication

KW - cortical synchronization

KW - dementia

KW - diagnostic imaging

KW - electroencephalography

KW - pathophysiology

KW - physiology

KW - psychology

KW - rest

KW - Aged

KW - Alzheimer Disease

KW - Cerebral Cortex

KW - Cognition

KW - Cortical Synchronization

KW - Dementia

KW - Electroencephalography

KW - Female

KW - Humans

KW - Lewy Body Disease

KW - Male

KW - Rest

U2 - 10.1016/j.neurobiolaging.2017.12.023

DO - 10.1016/j.neurobiolaging.2017.12.023

M3 - Article

VL - 65

SP - 18

EP - 40

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -