Abnormalities of sodium handling and of cardiovascular adaptations during high salt diet in patients with mild heart failure

Massimo Volpe, Cristina Tritto, Nicola DeLuca, Speranza Rubattu, Maria Assunta Elena Rao, Fausto Lamenza, Angelina Mirante, Iolanda Enea, Virgilio Rendina, Alessandro F. Mele, Bruno Trimarco, Mario Condorelli

Research output: Contribution to journalArticle

Abstract

Background. Sodium retention and hormonal activation are fundamental hallmarks in congestive heart failure. The present study was designed to assess the ability of patients with asymptomatic to mildly symptomatic heart failure and no signs or symptoms of congestion to excrete ingested sodium and to identify possible early abnormalities of hormonal and hemodynamic mechanisms related to sodium handling. Methods and Results. The effects of a high salt diet (250 mEq/day for 6 days) on hemodynamics, salt-regulating hormones, and renal excretory response were investigated in a balanced study in 12 untreated patients with idiopathic or ischemic dilated cardiomyopathy and mild heart failure (NYHA class I-II, ejection fraction

Original languageEnglish
Pages (from-to)1620-1627
Number of pages8
JournalCirculation
Volume88
Issue number4
Publication statusPublished - Oct 1993

Keywords

  • Cardiomyopathies
  • Diet
  • Heart failure
  • Kidney
  • Natriuretic factors
  • Renin
  • Sodium

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Volpe, M., Tritto, C., DeLuca, N., Rubattu, S., Rao, M. A. E., Lamenza, F., Mirante, A., Enea, I., Rendina, V., Mele, A. F., Trimarco, B., & Condorelli, M. (1993). Abnormalities of sodium handling and of cardiovascular adaptations during high salt diet in patients with mild heart failure. Circulation, 88(4), 1620-1627.