The results indicate that chronic autonomic insufficiency can be associated with altered circulatory dynamics even at rest in the supine position and in the absence of apparent stress. The circulatory disorder in idiopathic orthostatic hypotension (IOH) is not limited to failure of arteriolar vasoconstriction on standing up; the abnormalities uncovered ranged from a reduced plasma volume to depressed cardiac performance. Repeated observations have confirmed the initial observations of Ibrahim et al., regarding reduced cardiac output and low mean rate of left ventricular ejection in idiopathic orthostatic hypotension. Additinal evidence was found suggesting that impaired cardiac function may indeed play a contributory role in that disease. Furthermore an intriguing observation emerged, namely the contrast between a clear cut increase in peripheral resistance at rest and an apparent reduction in tone of the capacitance vessels.
|Number of pages||11|
|Publication status||Published - 1976|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine