Abnormalities of the contingent negative variation in Huntington's disease: Correlations with clinical features

Marina de Tommaso, Olimpia Difruscolo, Vittorio Sciruicchio, Nicola Specchio, Paolo Livrea

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The contingent negative variation (CNV) is a neurophysiological pattern related to planning of external - paced, voluntary movements. The aim of the study, was to examine the CNV in a cohort of mild demented and non-medicated HD patients, evaluating the CNV amplitude modifications in the light of clinical features and performing Low Resolution Brain Electromagnetic Tomography (LORETA) analysis in order to show the CNV multiple generators. Fourteen HD patients and 25 sex and age-matched controls were studied. All subjects were evaluated by the motor section of UHDRS, MMSE and WAIS. The CNV was recorded by 19 scalp electrodes, with a red light flash as visual warning stimulus (S1), followed by a blue light flash (S2) after a fixed interval of 3 s. The amplitude of early CNV was significantly reduced in HD, compared to controls: the amplitude reduction was significantly correlated with the bradikinesia score. LORETA analysis of early CNV significantly discriminated patients from controls, for a prevalent activation of the posterior part of anterior cingulate cortex in HD. An abnormal activation of the associative cortex devoted to the processing of attention preceding voluntary movement may be supposed in HD, probably mediated by the altered basal ganglia modulation.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalJournal of the Neurological Sciences
Volume254
Issue number1-2
DOIs
Publication statusPublished - Mar 15 2007

Fingerprint

Contingent Negative Variation
Huntington Disease
Electromagnetic Phenomena
Tomography
Light
Gyrus Cinguli
Brain
Basal Ganglia
Scalp
Electrodes

Keywords

  • Bradikinesia
  • Contingent negative variation
  • Huntington's disease
  • Motor programming

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Abnormalities of the contingent negative variation in Huntington's disease : Correlations with clinical features. / de Tommaso, Marina; Difruscolo, Olimpia; Sciruicchio, Vittorio; Specchio, Nicola; Livrea, Paolo.

In: Journal of the Neurological Sciences, Vol. 254, No. 1-2, 15.03.2007, p. 84-89.

Research output: Contribution to journalArticle

de Tommaso, Marina ; Difruscolo, Olimpia ; Sciruicchio, Vittorio ; Specchio, Nicola ; Livrea, Paolo. / Abnormalities of the contingent negative variation in Huntington's disease : Correlations with clinical features. In: Journal of the Neurological Sciences. 2007 ; Vol. 254, No. 1-2. pp. 84-89.
@article{1e3514ea7d13426da4e027f387cf8b1c,
title = "Abnormalities of the contingent negative variation in Huntington's disease: Correlations with clinical features",
abstract = "The contingent negative variation (CNV) is a neurophysiological pattern related to planning of external - paced, voluntary movements. The aim of the study, was to examine the CNV in a cohort of mild demented and non-medicated HD patients, evaluating the CNV amplitude modifications in the light of clinical features and performing Low Resolution Brain Electromagnetic Tomography (LORETA) analysis in order to show the CNV multiple generators. Fourteen HD patients and 25 sex and age-matched controls were studied. All subjects were evaluated by the motor section of UHDRS, MMSE and WAIS. The CNV was recorded by 19 scalp electrodes, with a red light flash as visual warning stimulus (S1), followed by a blue light flash (S2) after a fixed interval of 3 s. The amplitude of early CNV was significantly reduced in HD, compared to controls: the amplitude reduction was significantly correlated with the bradikinesia score. LORETA analysis of early CNV significantly discriminated patients from controls, for a prevalent activation of the posterior part of anterior cingulate cortex in HD. An abnormal activation of the associative cortex devoted to the processing of attention preceding voluntary movement may be supposed in HD, probably mediated by the altered basal ganglia modulation.",
keywords = "Bradikinesia, Contingent negative variation, Huntington's disease, Motor programming",
author = "{de Tommaso}, Marina and Olimpia Difruscolo and Vittorio Sciruicchio and Nicola Specchio and Paolo Livrea",
year = "2007",
month = "3",
day = "15",
doi = "10.1016/j.jns.2007.01.011",
language = "English",
volume = "254",
pages = "84--89",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Abnormalities of the contingent negative variation in Huntington's disease

T2 - Correlations with clinical features

AU - de Tommaso, Marina

AU - Difruscolo, Olimpia

AU - Sciruicchio, Vittorio

AU - Specchio, Nicola

AU - Livrea, Paolo

PY - 2007/3/15

Y1 - 2007/3/15

N2 - The contingent negative variation (CNV) is a neurophysiological pattern related to planning of external - paced, voluntary movements. The aim of the study, was to examine the CNV in a cohort of mild demented and non-medicated HD patients, evaluating the CNV amplitude modifications in the light of clinical features and performing Low Resolution Brain Electromagnetic Tomography (LORETA) analysis in order to show the CNV multiple generators. Fourteen HD patients and 25 sex and age-matched controls were studied. All subjects were evaluated by the motor section of UHDRS, MMSE and WAIS. The CNV was recorded by 19 scalp electrodes, with a red light flash as visual warning stimulus (S1), followed by a blue light flash (S2) after a fixed interval of 3 s. The amplitude of early CNV was significantly reduced in HD, compared to controls: the amplitude reduction was significantly correlated with the bradikinesia score. LORETA analysis of early CNV significantly discriminated patients from controls, for a prevalent activation of the posterior part of anterior cingulate cortex in HD. An abnormal activation of the associative cortex devoted to the processing of attention preceding voluntary movement may be supposed in HD, probably mediated by the altered basal ganglia modulation.

AB - The contingent negative variation (CNV) is a neurophysiological pattern related to planning of external - paced, voluntary movements. The aim of the study, was to examine the CNV in a cohort of mild demented and non-medicated HD patients, evaluating the CNV amplitude modifications in the light of clinical features and performing Low Resolution Brain Electromagnetic Tomography (LORETA) analysis in order to show the CNV multiple generators. Fourteen HD patients and 25 sex and age-matched controls were studied. All subjects were evaluated by the motor section of UHDRS, MMSE and WAIS. The CNV was recorded by 19 scalp electrodes, with a red light flash as visual warning stimulus (S1), followed by a blue light flash (S2) after a fixed interval of 3 s. The amplitude of early CNV was significantly reduced in HD, compared to controls: the amplitude reduction was significantly correlated with the bradikinesia score. LORETA analysis of early CNV significantly discriminated patients from controls, for a prevalent activation of the posterior part of anterior cingulate cortex in HD. An abnormal activation of the associative cortex devoted to the processing of attention preceding voluntary movement may be supposed in HD, probably mediated by the altered basal ganglia modulation.

KW - Bradikinesia

KW - Contingent negative variation

KW - Huntington's disease

KW - Motor programming

UR - http://www.scopus.com/inward/record.url?scp=33847289177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847289177&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2007.01.011

DO - 10.1016/j.jns.2007.01.011

M3 - Article

C2 - 17300807

AN - SCOPUS:33847289177

VL - 254

SP - 84

EP - 89

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -