Abnormalities of von Willebrand factor in myeloproliferative disease: A relationship with bleeding diathesis

F. Fabris, A. Casonato, M. Grazia Del Ben, L. De Marco, A. Girolami

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Abstract

We studied factor VIII related properties in 24 patients with increased platelet numbers. Twenty-one were affected by myeloproliferative disorders (eight had polycythaemia vera, 13 had essential thrombocythaemia) and three had secondary thrombocytosis. Normal levels of VIII:C and VIIIR:Ag were found while a significant (P <0.05) decrease of VIIIR:RCOF (43 ± 13%) related to a lack of larger multimers of VWF (39 ± 12%) was observed in 57% of patients with myeloproliferative disorders. A normal VWF pattern was found in the three patients with secondary thrombocytosis. The highest incidence of VWF abnormalities occurred in patients with essential thrombocythaemia (70%) in comparison with polycythaemic patients (38%). A significant (P <0.03) correlation between platelet count and the values of both VIIIR:RCOF and VWF multimeric pattern was observed only in patients with polycythaemia vera. The lowest levels of VIIIR:RCOF and the greatest loss of larger VWF multimers (less than 30%) were observed in two patients who presented bleeding symptoms at the time of study and a prolonged bleeding time. In addition, the relationship between VWF pattern and bleeding diathesis was supported by the fact that 75% of the patients with VWF abnormalities had bleeding history.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalBritish Journal of Haematology
Volume63
Issue number1
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Hematology

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Fabris, F., Casonato, A., Grazia Del Ben, M., De Marco, L., & Girolami, A. (1986). Abnormalities of von Willebrand factor in myeloproliferative disease: A relationship with bleeding diathesis. British Journal of Haematology, 63(1), 75-83.