Abnormality of α1-adrenergic receptors in the frontal cortex of epileptic rats

F. Nicoletti, M. L. Barbaccia, M. J. Iadarola, O. Pozzi, H. E. Laird

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Abstract

We found that the binding of [3H]prazosin, a selective ligand for α1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats. Scatchard analysis reveals a decrease in the B(max) of [3H]prazosin binding with no change in the apparent K(D), suggesting that there are fewer α1-adrenergic recognition sites in the frontal cortex of the GEPR. This abnormality is associated with a reduced capacity of norepinephrine (NE) to stimulate [3H]inositol monophosphate ([3H]IP1) formation in frontal cortex slices prelabeled with [3H]inositol. No significant differences in [3H]prazosin binding as well as NE-stimulated [3H]IP1 formation have been observed in other brain regions including hippocampus, corpus striatum, and inferior colliculus. These results indicate that a deficit in the α1-adrenergic receptor system in the frontal cortex may play a role in the seizure process in the GEPR.

Original languageEnglish
Pages (from-to)270-273
Number of pages4
JournalJournal of Neurochemistry
Volume46
Issue number1
DOIs
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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