Abolition and reversel of strain differences in behavioral responses to drugs of abuse after a brief experience

Simona Cabib, Cristina Orsini, Michel Le Moal, Pier Vincenzo Piazza

Research output: Contribution to journalArticle

Abstract

Inbred strains of mice are largely used to identify the genetic basis of normal and pathological behaviors. This report demonstrates that a moderate period of food shortage, an ecologically common experience, can reverse or abolish strain differences in behavioral responses to the abused psychostimulant amphetamine. The period of food shortage occurred when the animals were mature and was terminated before the administration of amphetamine. Strain differences in behavior appear highly dependent on environmental experiences. Consequently, to identify biological determinants of behavior, an integrated approach considering the interaction between environmental and genetic factors needs to be used.

Original languageEnglish
Pages (from-to)463-465
Number of pages3
JournalScience
Volume289
Issue number5478
DOIs
Publication statusPublished - Jul 21 2000

ASJC Scopus subject areas

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