Absence of angiogenic genes modification in Italian ALS patients

Roberto Del Bo, Marina Scarlato, Serena Ghezzi, Filippo Martinelli-Boneschi, Stefania Corti, Federica Locatelli, Domenico Santoro, Alessandro Prelle, Chiara Briani, Martina Nardini, Gabriele Siciliano, Michelangelo Mancuso, Luigi Murri, Nereo Bresolin, Giacomo Pietro Comi

Research output: Contribution to journalArticle

Abstract

To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients. VEGF genotype and haplotype analysis revealed no association between any variants and the risk of ALS. Regarding ANG gene, no mutation was detected and the rs11701 polymorphism, previously described as associated with ALS, was not differently distributed between patients and controls. Overall, our data argue against the hypothesis of both genes as risk factors for motoneuron neurodegeneration, at least in an Italian population.

Original languageEnglish
Pages (from-to)314-316
Number of pages3
JournalNeurobiology of Aging
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Keywords

  • Amyotrophic lateral sclerosis
  • Angiogenin
  • Genetic risk factor
  • Meta-analysis
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Del Bo, R., Scarlato, M., Ghezzi, S., Martinelli-Boneschi, F., Corti, S., Locatelli, F., Santoro, D., Prelle, A., Briani, C., Nardini, M., Siciliano, G., Mancuso, M., Murri, L., Bresolin, N., & Comi, G. P. (2008). Absence of angiogenic genes modification in Italian ALS patients. Neurobiology of Aging, 29(2), 314-316. https://doi.org/10.1016/j.neurobiolaging.2006.10.008