Absence of antibodies to human herpesvirus-6 in patients with slowly-progressive human immunodeficiency virus type I infection

H. Chen, A. M. Pesce, M. Carbonari, F. Ensoli, M. Cherchi, G. Campitelli, D. Sbarigia, G. Luzi, F. Aiuti, M. Fiorilli

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate a possible role for Human Herpesvirus-type 6 (HHV-6) coinfection as a co-factor in the progression of HIV-1 disease, we investigated the prevalence of seropositivity for HHV-6 in a cohort of HIV-1 infected patients. These patients were retrospectively divided into two groups according to the decline of CD4+ T cells during the follow up: 11 were classified as rapid decliners (<400 CD4+/cmm within 1 year), and 38 as slow decliners (> 400 CD4+/cmm after at least 4 years' follow up). HHV-6 antibodies were detected by a commercial immunofluorescence assay and by a Western blotting assay developed in our laboratory. Our results show that Western blot appears to provide results satisfactorily free of false positivities. We found that the frequency of HHV-6 seropositivity was significantly lower in the group of slow decliners, compared both to rapid decliners and to the general population. These data suggest a role for HHV-6 co-infection in the progression of HIV-1 disease.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalEuropean Journal of Epidemiology
Volume8
Issue number2
DOIs
Publication statusPublished - Mar 1992

Keywords

  • CD4
  • HHV-6
  • HIV-1
  • Progression rate

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Absence of antibodies to human herpesvirus-6 in patients with slowly-progressive human immunodeficiency virus type I infection'. Together they form a unique fingerprint.

Cite this