Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE

Y. Q. Song, E. Rogaeva, S. Premkumar, N. Brindle, T. Kawarai, An Orlacchio, G. Yu, G. Levesque, M. Nishimura, M. Ikeda, Y. Pei, C. O'Toole, R. Duara, W. Barker, S. Sorbi, M. Freedman, L. Farrer, P. St. George-Hyslop

Research output: Contribution to journalArticle

Abstract

A novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recently been reported to be associated with risk for Alzheimer disease (AD). To test this association in an independent data set, we have examined this polymorphism in a sample of 88 well-characterized AD cases and compared the allele frequency and genotype frequencies for this polymorphism with those observed in 112 cegnitively normal subjects drawn from the same ethnic group. These results suggest that in the current data set at least, the -491 NT polymorphism is not associated with risk for AD, but may be in partial linkage disequilibrium with the APOE ε2/ε3/ε4 polymorphism.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalNeuroscience Letters
Volume250
Issue number3
DOIs
Publication statusPublished - Jul 10 1998

Keywords

  • -491 A/T polymorphism
  • Alzheimer disease
  • APOE ε2/ε3/ε4 polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE'. Together they form a unique fingerprint.

  • Cite this

    Song, Y. Q., Rogaeva, E., Premkumar, S., Brindle, N., Kawarai, T., Orlacchio, A., Yu, G., Levesque, G., Nishimura, M., Ikeda, M., Pei, Y., O'Toole, C., Duara, R., Barker, W., Sorbi, S., Freedman, M., Farrer, L., & St. George-Hyslop, P. (1998). Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE. Neuroscience Letters, 250(3), 189-192. https://doi.org/10.1016/S0304-3940(98)00470-4