Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas

S. C. Edmunds, I. A. Cree, F. Dí Nícolantonío, J. L. Hungerford, J. S. Hurren, D. P. Kelsell

Research output: Contribution to journalArticlepeer-review

Abstract

The recent discovery of activating mutations in the BRAF gene in many cutaneous melanomas led us to screen the genomic sequence of BRAF exons 11 and 15 in a series of 48 intraocular (uveal) melanomas, together with control samples from three cutaneous melanomas and the SK-Mel-28 cell line, which has a BRAF mutation. The same mutation was detected in two-thirds of our cutaneous melanoma samples, but was not present in any uveal melanomas. This finding further underlines the distinction between uveal and cutaneous melanomas, and suggests that BRAF inhibitors are unlikely to benefit patients with uveal melanoma.

Original languageEnglish
Pages (from-to)1403-1405
Number of pages3
JournalBritish Journal of Cancer
Volume88
Issue number9
DOIs
Publication statusPublished - May 6 2003

Keywords

  • BRAF
  • DNA sequence
  • Melanoma
  • Mutation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas'. Together they form a unique fingerprint.

Cite this