Absence of clinical signs of cardiac denervation after percutaneous myocardial laser revascularization

Stefano Guzzetti, Alessandro Colombo, Emanuela Piccaluga, Luca Tagliabue, Renata Magatelli, Giulia Cantoni, Maurizio Viecca

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Percutaneous myocardial revascularization with laser (PMR) is a catheter-based technique that has generated much interest in the treatment of patients with severe coronary artery disease. Several mechanisms have been proposed to explain the reported clinical benefits of this technique. Cardiac autonomic denervation is among these. Methods: We studied 32 consecutive patients with chronic severe angina not suitable for other revascularization approaches. Canadian Class Society (CCS) class clinical assessment, Naughton exercise stress test, and scintigraphic myocardial perfusion were evaluated before and 1 and 6 months after PMR. Ewing's autonomic tests, heart rate variability (HRV), and plasmatic catecholamines were assessed before revascularization in non-diabetic and diabetic patients and repeated 1 month after PMR in 13 non-diabetics. A psychological test was carried out before PMR to evaluate the attitude towards this new procedure. Results: All the markers of autonomic cardiac control were unmodified after the procedure. Moreover, scintigraphic perfusion measured in the lasered areas was similar before and after the procedure. On the other hand, the clinical conditions significantly improved (CCS class from 3±0.8 to 1.9±0.9 at 1 month, P

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalInternational Journal of Cardiology
Volume91
Issue number2-3
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Myocardial Revascularization
Denervation
Lasers
Exercise Test
Autonomic Denervation
Perfusion
Psychological Tests
Catecholamines
Coronary Artery Disease
Catheters
Heart Rate
Therapeutics

Keywords

  • Angina
  • Coronary disease
  • Laser
  • Nervous automatic system
  • Revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Absence of clinical signs of cardiac denervation after percutaneous myocardial laser revascularization. / Guzzetti, Stefano; Colombo, Alessandro; Piccaluga, Emanuela; Tagliabue, Luca; Magatelli, Renata; Cantoni, Giulia; Viecca, Maurizio.

In: International Journal of Cardiology, Vol. 91, No. 2-3, 10.2003, p. 129-135.

Research output: Contribution to journalArticle

Guzzetti, Stefano ; Colombo, Alessandro ; Piccaluga, Emanuela ; Tagliabue, Luca ; Magatelli, Renata ; Cantoni, Giulia ; Viecca, Maurizio. / Absence of clinical signs of cardiac denervation after percutaneous myocardial laser revascularization. In: International Journal of Cardiology. 2003 ; Vol. 91, No. 2-3. pp. 129-135.
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