Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women

S. Semprini, R. Mango, F. Brancati, B. Dallapiccola, L. Becherini, G. Novelli, A. De Lorenzo, M. L. Brandi, L. Gennari

Research output: Contribution to journalArticlepeer-review

Abstract

Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We investigated the association of BMP-4 gene polymorphism with osteoporosis in a cohort of 72 osteoporotic, postmenopausal women and 82 unrelated controls. We failed to detect any significant association between this genetic marker and the disease.

Original languageEnglish
Pages (from-to)93-94
Number of pages2
JournalCalcified Tissue International
Volume67
Issue number1
Publication statusPublished - 2000

Keywords

  • BMP-4
  • Genetic association
  • Osteoporosis
  • SNP

ASJC Scopus subject areas

  • Endocrinology

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