Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women

S. Semprini, R. Mango, F. Brancati, B. Dallapiccola, L. Becherini, G. Novelli, A. De Lorenzo, M. L. Brandi, L. Gennari

Research output: Contribution to journalArticle

Abstract

Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We investigated the association of BMP-4 gene polymorphism with osteoporosis in a cohort of 72 osteoporotic, postmenopausal women and 82 unrelated controls. We failed to detect any significant association between this genetic marker and the disease.

Original languageEnglish
Pages (from-to)93-94
Number of pages2
JournalCalcified Tissue International
Volume67
Issue number1
Publication statusPublished - 2000

Fingerprint

Bone Morphogenetic Protein 4
Postmenopausal Osteoporosis
Osteoporosis
Bone Morphogenetic Proteins
Inborn Genetic Diseases
Bone Remodeling
Osteoblasts
Genetic Markers
Genes
Regeneration
Phenotype
Bone and Bones
Proteins

Keywords

  • BMP-4
  • Genetic association
  • Osteoporosis
  • SNP

ASJC Scopus subject areas

  • Endocrinology

Cite this

Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women. / Semprini, S.; Mango, R.; Brancati, F.; Dallapiccola, B.; Becherini, L.; Novelli, G.; De Lorenzo, A.; Brandi, M. L.; Gennari, L.

In: Calcified Tissue International, Vol. 67, No. 1, 2000, p. 93-94.

Research output: Contribution to journalArticle

Semprini, S, Mango, R, Brancati, F, Dallapiccola, B, Becherini, L, Novelli, G, De Lorenzo, A, Brandi, ML & Gennari, L 2000, 'Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women', Calcified Tissue International, vol. 67, no. 1, pp. 93-94.
Semprini, S. ; Mango, R. ; Brancati, F. ; Dallapiccola, B. ; Becherini, L. ; Novelli, G. ; De Lorenzo, A. ; Brandi, M. L. ; Gennari, L. / Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women. In: Calcified Tissue International. 2000 ; Vol. 67, No. 1. pp. 93-94.
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