Absence of FGFR3–TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration

C. Banella, M. Ginevrino, G. Catalano, E. Fabiani, G. Falconi, M. Divona, P. Curzi, P. Panetta, M. T. Voso, N. I. Noguera

Research output: Contribution to journalArticlepeer-review

Abstract

FGFR–TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR–TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3–TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended.

Original languageEnglish
JournalHematology/ Oncology and Stem Cell Therapy
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Acute myeloid leukemia
  • Aneuploidy
  • FGFR3–TACC3
  • Glioblastoma
  • Myelodysplastic syndromes

ASJC Scopus subject areas

  • Hematology
  • Oncology

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