Abstract
FGFR–TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR–TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3–TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended.
Original language | English |
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Journal | Hematology/ Oncology and Stem Cell Therapy |
DOIs | |
Publication status | Accepted/In press - 2021 |
Keywords
- Acute myeloid leukemia
- Aneuploidy
- FGFR3–TACC3
- Glioblastoma
- Myelodysplastic syndromes
ASJC Scopus subject areas
- Hematology
- Oncology