Absence of hemolytic potential of ofloxacin toward glucose-6-phosphate dehydrogenase-deficient erythrocytes

G. F. Gaetani, S. Galiano, M. Miglino, L. Canepa, A. M. Ferraris

Research output: Contribution to journalArticle

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Abstract

Some drugs can cause hemolysis in glucose-6-phosphate dehydrogenase (G6PD)-deficient subjects. We studied the potential hemolytic effect of ofloxacin, a 4-quinolone antibiotic, in vitro. Drugs that may be hemolytic for glucose-6-phosphate-deficient erythrocytes stimulate the hexose monophosphate shunt of normal erythrocytes and cause oxidation of reduced glutathione and reduced nicotinamide-adenine dinucleotide phosphate in deficient red cells. Blood from ten normal subjects and five G6PD-deficient patients was tested in vitro in the presence of different concentrations of ofloxacin. No significant metabolic modifications were observed, either in normal or in G6PD-deficient red cells; ofloxacin may therefore be safely used in those countries having a high incidence of G6PD deficiency.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalCurrent Therapeutic Research
Volume49
Issue number3
Publication statusPublished - 1991

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Ofloxacin
Glucosephosphate Dehydrogenase
Erythrocytes
4-Quinolones
Glucosephosphate Dehydrogenase Deficiency
Pentose Phosphate Pathway
Glucose-6-Phosphate
Hemolysis
NADP
Pharmaceutical Preparations
Glutathione
Anti-Bacterial Agents
Incidence
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Absence of hemolytic potential of ofloxacin toward glucose-6-phosphate dehydrogenase-deficient erythrocytes. / Gaetani, G. F.; Galiano, S.; Miglino, M.; Canepa, L.; Ferraris, A. M.

In: Current Therapeutic Research, Vol. 49, No. 3, 1991, p. 329-334.

Research output: Contribution to journalArticle

Gaetani, G. F. ; Galiano, S. ; Miglino, M. ; Canepa, L. ; Ferraris, A. M. / Absence of hemolytic potential of ofloxacin toward glucose-6-phosphate dehydrogenase-deficient erythrocytes. In: Current Therapeutic Research. 1991 ; Vol. 49, No. 3. pp. 329-334.
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