Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis

C. Taus, E. Pucci, E. Cartechini, A. Fié, G. Giuliani, M. Clementi, S. Menzo

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Objective - To contribute to clarifying the controversy on the association between Human Herpesviruses 6 and 7 (HHV-6, HHV-7) and multiple sclerosis (MS) studying patients with relapsing-remitting MS (RRMS) with or without evidence of disease activity (clinically or radiologically evaluated). Material and methods - In 25 RRMS patients, 7 suspected MS patients and 9 patients with other neurological diseases, the following parameters were analysed: i) antibody titers (IgM and IgG) against HHV-6 by indirect immunofluorescence both in serum and cerebrospinal fluid (CSF) samples; ii) PCR-detection of HHV-6 DNA and HHV-7 DNA in CSF and HHV-6 DNA in peripheral blood mononuclear cells (PBMCs). MS patients in remission underwent a gadolinium-enhanced magnetic resonance imaging in proximity of sample collections. Results - No viral DNA was found in any CSF sample, HHV-6 DNA frequency in PBMCs of MS patients and controls was not statistically different. Antibody titers against HHV-6 were comparable to those of the general population. Some 30.4% of MS patients were seronegative to HHV6. Conclusion - Our data suggest that there is no relationship between HHV-6 or HHV-7 and MS.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalActa Neurologica Scandinavica
Volume101
Issue number4
Publication statusPublished - 2000

Fingerprint

Human Herpesvirus 7
Human Herpesvirus 6
Relapsing-Remitting Multiple Sclerosis
Cerebrospinal Fluid
Multiple Sclerosis
DNA
Blood Cells
Antibodies
Viral DNA
Gadolinium
Indirect Fluorescent Antibody Technique
Immunoglobulin M
Immunoglobulin G
Magnetic Resonance Imaging

Keywords

  • Herpesvirus
  • HHV-6
  • HHV-7
  • Relapsing-remitting multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Taus, C., Pucci, E., Cartechini, E., Fié, A., Giuliani, G., Clementi, M., & Menzo, S. (2000). Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis. Acta Neurologica Scandinavica, 101(4), 224-228.

Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis. / Taus, C.; Pucci, E.; Cartechini, E.; Fié, A.; Giuliani, G.; Clementi, M.; Menzo, S.

In: Acta Neurologica Scandinavica, Vol. 101, No. 4, 2000, p. 224-228.

Research output: Contribution to journalArticle

Taus, C, Pucci, E, Cartechini, E, Fié, A, Giuliani, G, Clementi, M & Menzo, S 2000, 'Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis', Acta Neurologica Scandinavica, vol. 101, no. 4, pp. 224-228.
Taus, C. ; Pucci, E. ; Cartechini, E. ; Fié, A. ; Giuliani, G. ; Clementi, M. ; Menzo, S. / Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis. In: Acta Neurologica Scandinavica. 2000 ; Vol. 101, No. 4. pp. 224-228.
@article{a4f54d411f2841be831f333776c08e36,
title = "Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis",
abstract = "Objective - To contribute to clarifying the controversy on the association between Human Herpesviruses 6 and 7 (HHV-6, HHV-7) and multiple sclerosis (MS) studying patients with relapsing-remitting MS (RRMS) with or without evidence of disease activity (clinically or radiologically evaluated). Material and methods - In 25 RRMS patients, 7 suspected MS patients and 9 patients with other neurological diseases, the following parameters were analysed: i) antibody titers (IgM and IgG) against HHV-6 by indirect immunofluorescence both in serum and cerebrospinal fluid (CSF) samples; ii) PCR-detection of HHV-6 DNA and HHV-7 DNA in CSF and HHV-6 DNA in peripheral blood mononuclear cells (PBMCs). MS patients in remission underwent a gadolinium-enhanced magnetic resonance imaging in proximity of sample collections. Results - No viral DNA was found in any CSF sample, HHV-6 DNA frequency in PBMCs of MS patients and controls was not statistically different. Antibody titers against HHV-6 were comparable to those of the general population. Some 30.4{\%} of MS patients were seronegative to HHV6. Conclusion - Our data suggest that there is no relationship between HHV-6 or HHV-7 and MS.",
keywords = "Herpesvirus, HHV-6, HHV-7, Relapsing-remitting multiple sclerosis",
author = "C. Taus and E. Pucci and E. Cartechini and A. Fi{\'e} and G. Giuliani and M. Clementi and S. Menzo",
year = "2000",
language = "English",
volume = "101",
pages = "224--228",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley Blackwell",
number = "4",

}

TY - JOUR

T1 - Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis

AU - Taus, C.

AU - Pucci, E.

AU - Cartechini, E.

AU - Fié, A.

AU - Giuliani, G.

AU - Clementi, M.

AU - Menzo, S.

PY - 2000

Y1 - 2000

N2 - Objective - To contribute to clarifying the controversy on the association between Human Herpesviruses 6 and 7 (HHV-6, HHV-7) and multiple sclerosis (MS) studying patients with relapsing-remitting MS (RRMS) with or without evidence of disease activity (clinically or radiologically evaluated). Material and methods - In 25 RRMS patients, 7 suspected MS patients and 9 patients with other neurological diseases, the following parameters were analysed: i) antibody titers (IgM and IgG) against HHV-6 by indirect immunofluorescence both in serum and cerebrospinal fluid (CSF) samples; ii) PCR-detection of HHV-6 DNA and HHV-7 DNA in CSF and HHV-6 DNA in peripheral blood mononuclear cells (PBMCs). MS patients in remission underwent a gadolinium-enhanced magnetic resonance imaging in proximity of sample collections. Results - No viral DNA was found in any CSF sample, HHV-6 DNA frequency in PBMCs of MS patients and controls was not statistically different. Antibody titers against HHV-6 were comparable to those of the general population. Some 30.4% of MS patients were seronegative to HHV6. Conclusion - Our data suggest that there is no relationship between HHV-6 or HHV-7 and MS.

AB - Objective - To contribute to clarifying the controversy on the association between Human Herpesviruses 6 and 7 (HHV-6, HHV-7) and multiple sclerosis (MS) studying patients with relapsing-remitting MS (RRMS) with or without evidence of disease activity (clinically or radiologically evaluated). Material and methods - In 25 RRMS patients, 7 suspected MS patients and 9 patients with other neurological diseases, the following parameters were analysed: i) antibody titers (IgM and IgG) against HHV-6 by indirect immunofluorescence both in serum and cerebrospinal fluid (CSF) samples; ii) PCR-detection of HHV-6 DNA and HHV-7 DNA in CSF and HHV-6 DNA in peripheral blood mononuclear cells (PBMCs). MS patients in remission underwent a gadolinium-enhanced magnetic resonance imaging in proximity of sample collections. Results - No viral DNA was found in any CSF sample, HHV-6 DNA frequency in PBMCs of MS patients and controls was not statistically different. Antibody titers against HHV-6 were comparable to those of the general population. Some 30.4% of MS patients were seronegative to HHV6. Conclusion - Our data suggest that there is no relationship between HHV-6 or HHV-7 and MS.

KW - Herpesvirus

KW - HHV-6

KW - HHV-7

KW - Relapsing-remitting multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0034066567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034066567&partnerID=8YFLogxK

M3 - Article

VL - 101

SP - 224

EP - 228

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 4

ER -