Abstract
Background: In normal humans, variability of blood pressure, RR interval, and sympathetic activity occurs predominantly at a low frequency (LF; 0.04 to 0.14 Hz) and a high frequency (HF; ±0.25 Hz). In conditions that increase sympathetic activation in normal humans, the LF component is increased relative to the HF component. Patients with heart failure have high levels of sympathetic activity. We tested the hypothesis that the LF component of sympathetic nerve activity variability is increased in heart failure. Methods and Results: We performed spectral analysis of simultaneous recordings of resting muscle sympathetic nerve activity (MSNA) and RR interval in 21 patients with chronic heart failure and 12 age-matched control subjects. MSNA was higher in patients with heart failure (62±4 bursts per minute) than in the normal subjects (39±4 bursts per minute; P
| Original language | English |
|---|---|
| Pages (from-to) | 1449-1454 |
| Number of pages | 6 |
| Journal | Circulation |
| Volume | 95 |
| Issue number | 6 |
| Publication status | Published - 1997 |
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Keywords
- autonomic nervous system
- heart failure
- heart rate
- respiration
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Absence of low-frequency variability of sympathetic nerve activity in severe heart failure. / Van De Borne, Philippe; Montano, Nicola; Pagani, Massimo; Oren, Ron; Somers, Virend K.
In: Circulation, Vol. 95, No. 6, 1997, p. 1449-1454.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Absence of low-frequency variability of sympathetic nerve activity in severe heart failure
AU - Van De Borne, Philippe
AU - Montano, Nicola
AU - Pagani, Massimo
AU - Oren, Ron
AU - Somers, Virend K.
PY - 1997
Y1 - 1997
N2 - Background: In normal humans, variability of blood pressure, RR interval, and sympathetic activity occurs predominantly at a low frequency (LF; 0.04 to 0.14 Hz) and a high frequency (HF; ±0.25 Hz). In conditions that increase sympathetic activation in normal humans, the LF component is increased relative to the HF component. Patients with heart failure have high levels of sympathetic activity. We tested the hypothesis that the LF component of sympathetic nerve activity variability is increased in heart failure. Methods and Results: We performed spectral analysis of simultaneous recordings of resting muscle sympathetic nerve activity (MSNA) and RR interval in 21 patients with chronic heart failure and 12 age-matched control subjects. MSNA was higher in patients with heart failure (62±4 bursts per minute) than in the normal subjects (39±4 bursts per minute; P
AB - Background: In normal humans, variability of blood pressure, RR interval, and sympathetic activity occurs predominantly at a low frequency (LF; 0.04 to 0.14 Hz) and a high frequency (HF; ±0.25 Hz). In conditions that increase sympathetic activation in normal humans, the LF component is increased relative to the HF component. Patients with heart failure have high levels of sympathetic activity. We tested the hypothesis that the LF component of sympathetic nerve activity variability is increased in heart failure. Methods and Results: We performed spectral analysis of simultaneous recordings of resting muscle sympathetic nerve activity (MSNA) and RR interval in 21 patients with chronic heart failure and 12 age-matched control subjects. MSNA was higher in patients with heart failure (62±4 bursts per minute) than in the normal subjects (39±4 bursts per minute; P
KW - autonomic nervous system
KW - heart failure
KW - heart rate
KW - respiration
UR - http://www.scopus.com/inward/record.url?scp=0030934420&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030934420&partnerID=8YFLogxK
M3 - Article
C2 - 9118512
AN - SCOPUS:0030934420
VL - 95
SP - 1449
EP - 1454
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 6
ER -