Absence of neuroinvasive disease in a liver transplant recipient who acquired west nile virus (WNV) infection from the organ donor and who received WNV antibodies prophylactically

Maria Cristina Morelli, Vittorio Sambri, Gian Luca Grazi, Paolo Gaibani, Anna Pierro, Matteo Cescon, Giorgio Ercolani, Francesca Cavrini, Giada Rossini, Maria Rosaria Capobianchi, Antonino Di Caro, Stefano Menzo, Pasquale Paolo Pagliaro, Florio Ghinelli, Tiziana Lazzarotto, Maria Paola Landini, Antonio Daniele Pinna

Research output: Contribution to journalArticle

Abstract

We describe the first case of West Nile virus infection in Europe with transmission from donor to recipient following liver transplantation. The infection was detected in the recipient 3 days after transplantation, during the asymptomatic phase. We also report an innovative prophylactic strategy based on infusion of West Nile virus hyperimmune plasma and gamma globulins that could be effective in preventing the appearance of a neuroinvasive disease.

Original languageEnglish
JournalClinical Infectious Diseases
Volume51
Issue number4
DOIs
Publication statusPublished - Aug 15 2010

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Medicine(all)

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  • Cite this

    Morelli, M. C., Sambri, V., Grazi, G. L., Gaibani, P., Pierro, A., Cescon, M., Ercolani, G., Cavrini, F., Rossini, G., Capobianchi, M. R., Di Caro, A., Menzo, S., Pagliaro, P. P., Ghinelli, F., Lazzarotto, T., Landini, M. P., & Pinna, A. D. (2010). Absence of neuroinvasive disease in a liver transplant recipient who acquired west nile virus (WNV) infection from the organ donor and who received WNV antibodies prophylactically. Clinical Infectious Diseases, 51(4). https://doi.org/10.1086/655146