TY - JOUR
T1 - Absence of oligoclonally restricted immunoglobulins in tears from multiple sclerosis patients
AU - Martino, Gianvito
AU - Servalli, Cristina
AU - Filippi, Massimo
AU - Maurizio, Buscemi
AU - Martinelli, Vittorio
AU - Furlan, Roberto
AU - Comi, Giancarlo
AU - Grimaldi, Luigi M E
PY - 1993
Y1 - 1993
N2 - To study the extent of systemic immunodysregulation in multiple sclerosis (MS) we measured immunoglobulin (Ig)G, A, and M levels and studied their migrational properties after agarose isoelectric focusing in serum, cerebrospinal fluid (CSF) and tear samples from 18 MS patients with other neurological diseases (OND), and tears and serum samples from ten normal controls (NC). A slight elevation of total IgG, IgM and IgA levels was detected in tears from patients with MS and OND compared to NC. Of the five patients (two MS, three OND) that showed IgG oligoclonal bands (OCB) in tears, only one MS patient showed unique bands in tears not seen in the paired CSF and serum. We never found IgA, and IgM OCB in serum, CSF or tear samples. Our results suggest that polyclonal Igs are systemically elevated during chornic neurological inflammatory diseases. Oligoclonal Ig in MS, although ocassionally detectable in tears, is mainly confined to the central nervous system and appears restricted to class G.
AB - To study the extent of systemic immunodysregulation in multiple sclerosis (MS) we measured immunoglobulin (Ig)G, A, and M levels and studied their migrational properties after agarose isoelectric focusing in serum, cerebrospinal fluid (CSF) and tear samples from 18 MS patients with other neurological diseases (OND), and tears and serum samples from ten normal controls (NC). A slight elevation of total IgG, IgM and IgA levels was detected in tears from patients with MS and OND compared to NC. Of the five patients (two MS, three OND) that showed IgG oligoclonal bands (OCB) in tears, only one MS patient showed unique bands in tears not seen in the paired CSF and serum. We never found IgA, and IgM OCB in serum, CSF or tear samples. Our results suggest that polyclonal Igs are systemically elevated during chornic neurological inflammatory diseases. Oligoclonal Ig in MS, although ocassionally detectable in tears, is mainly confined to the central nervous system and appears restricted to class G.
KW - Immunoglobulins
KW - Multiple sclerosis
KW - Oligoclonal bands
KW - Tears
UR - http://www.scopus.com/inward/record.url?scp=0027161431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027161431&partnerID=8YFLogxK
U2 - 10.1016/0165-5728(93)90036-X
DO - 10.1016/0165-5728(93)90036-X
M3 - Article
C2 - 8505405
AN - SCOPUS:0027161431
VL - 44
SP - 149
EP - 155
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 2
ER -