ANCA are thought to play a pathogenetic role in renal vasculitis. Nevertheless, ANCA may sometimes be detected also in patients with diseases not usually associated with renal pathologies, such as ulcerative colitis. Our study was carried out to determine if the presence of ANCA in patients with ulcerative colitis was associated with any renal laboratory abnormalities. Eight ANCA-positive and 6 ANCA-negative patients with endoscopically and histologically proved diagnosis of active ulcerative colitis were investigated. Repeated, complete urinalyses and creatinine clearance were performed. ANCA were sought in all patients by indirect immunofluorescence and, when detected, were further characterized by ELISA using alphagranule preparation, mieloperoxidase, lactoferrine and catepsine. In both ANCA-positive and ANCA-negative patients renal function was normal or near normal and urinalyses failed to disclose any abnormalities. ANCA exhibited a perinuclear pattern in all (ANCA-positive) patients. None of the ANCA-positive patients had antibodies to mieloperoxidase or to alphagranules and only one had antibodies to lactoferrine; in the remnant, the ANCA specificity remained unknown. Our observations suggest that, since a) no renal damage is present in ANCA-positive patients with ulcerative colitis and b) the ANCA found in these patients do not share the antigenic targets with those commonly found in renal vasculitis, the potential of ANCA to induce renal lesions (if any) is strictly dependent on their own antigenic specificity.
|Translated title of the contribution||Absence of renal involvement in ANCA-positive patients with ulcerative colitis|
|Number of pages||6|
|Journal||Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia|
|Publication status||Published - 1994|
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