Absence of sleep EEG markers in fatal familial insomnia healthy carriers: A spectral analysis study

Franco Ferrillo, Giuseppe Plazzi, Lino Nobili, Manolo Beelke, Fabrizio De Carli, Pietro Cortelli, Paolo Tinuper, Patrizia Avoni, S. Vandi, Pierluigi Gambetti, Elio Lugaresi, Pasquale Montagna

Research output: Contribution to journalArticle

Abstract

Objectives: Fatal familial insomnia (FFI) is linked to a mutation at codon 178 (C178) of the prion protein gene (PRNP). FFI is pathologically characterized by selective atrophy of the anteroventral and mediodorsal thalamic nuclei and clinically by loss of sleep, dysautonomia and motor signs. A key early polysomnographic sign of the disease onset is the loss of sleep spindling (sigma activity, SA). In FFI the loss of SA leads to the spectral representation of a sudden slow wave activity (SWA) increase from an awake state, the reaching of a stable plateau without oscillations, followed by abrupt fall down to REM sleep. We evaluated the presence of differences in the spectral sleep EEG pattern in FFI relatives carriers (C178pos) or non-carriers (C178neg) of the C178 mutation. Methods: Seventeen healthy relatives of FFI patients, 8 carriers of the C178 FFI mutation in a preclinical condition and 9 non carriers, underwent two-night polysomnography. The absolute and relative EEG power of the 4 main bands (delta: SWA, 0.5-4.0 Hz; theta: TB, 4.5-8 Hz; alpha: AB, 8.5-12 Hz; sigma: SA, 12.5-16 Hz) has been studied for the total sleep time, the period of delta increase after sleep onset, and the period of delta plateau. Multiple regression has been applied to investigate relations between the power of the bands studied and 3 parameters: age, the gender of the subjects and the C178 genotype. Results: Our study could not show evidence of differences in the sleep EEG composition between carriers and non-carriers of the C178 FFI mutation. Conclusions: The spectral analysis techniques we used were not able to disclose sleep EEG markers linked to the FFI C178pos in the preclinical condition. Key sleep EEG alteration become evident only at the clinical onset of the disease.

Original languageEnglish
Pages (from-to)1888-1892
Number of pages5
JournalClinical Neurophysiology
Volume112
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • Fatal familial insomnia
  • Healthy carriers
  • Sleep EEG markers
  • Spectral analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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