Absence of thyrotropin-induced increase in leptin levels in patients with history of differentiated thyroid carcinoma undergoing recombinant human thyrotropin testing

F. Cecoli, G. Andraghetti, C. Ghiara, L. Briatore, D. Cavallero, M. Mussap, F. Minuto, M. Giusti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce interleukin-6 secretion by adipocytes. Leptin is the main protein secreted by adipose tissue. Objective: The aim of our study was to evaluate the acute effect of the recombinant human TSH (rhTSH)-induced TSH surge on serum leptin levels in thyroidectomized patients undergoing levothyroxine (L-T4) suppressive therapy for differentiated thyroid carcinoma (DTC). Design: A cohort of 15 female DTC patients was evaluated. Standard rhTSH testing was performed. Leptin, TSH, thyroid hormones, and thyroglobulin were measured before and 3, 6, and 9 days after rhTSH testing. Some metabolic parameters were also evaluated at the baseline. Results: Baseline leptin levels were 12.2±3.2 μg/l. Only body mass index (BMI) correlated significantly (p

Original languageEnglish
Pages (from-to)888-892
Number of pages5
JournalJournal of Endocrinological Investigation
Volume31
Issue number10
Publication statusPublished - Oct 2008

Keywords

  • Differentiated thyroid carcinoma
  • Leptin
  • rhTSH

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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