TY - JOUR
T1 - Absence of thyrotropin-induced increase in leptin levels in patients with history of differentiated thyroid carcinoma undergoing recombinant human thyrotropin testing
AU - Cecoli, F.
AU - Andraghetti, G.
AU - Ghiara, C.
AU - Briatore, L.
AU - Cavallero, D.
AU - Mussap, M.
AU - Minuto, F.
AU - Giusti, M.
PY - 2008/10
Y1 - 2008/10
N2 - Background: Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce interleukin-6 secretion by adipocytes. Leptin is the main protein secreted by adipose tissue. Objective: The aim of our study was to evaluate the acute effect of the recombinant human TSH (rhTSH)-induced TSH surge on serum leptin levels in thyroidectomized patients undergoing levothyroxine (L-T4) suppressive therapy for differentiated thyroid carcinoma (DTC). Design: A cohort of 15 female DTC patients was evaluated. Standard rhTSH testing was performed. Leptin, TSH, thyroid hormones, and thyroglobulin were measured before and 3, 6, and 9 days after rhTSH testing. Some metabolic parameters were also evaluated at the baseline. Results: Baseline leptin levels were 12.2±3.2 μg/l. Only body mass index (BMI) correlated significantly (p
AB - Background: Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce interleukin-6 secretion by adipocytes. Leptin is the main protein secreted by adipose tissue. Objective: The aim of our study was to evaluate the acute effect of the recombinant human TSH (rhTSH)-induced TSH surge on serum leptin levels in thyroidectomized patients undergoing levothyroxine (L-T4) suppressive therapy for differentiated thyroid carcinoma (DTC). Design: A cohort of 15 female DTC patients was evaluated. Standard rhTSH testing was performed. Leptin, TSH, thyroid hormones, and thyroglobulin were measured before and 3, 6, and 9 days after rhTSH testing. Some metabolic parameters were also evaluated at the baseline. Results: Baseline leptin levels were 12.2±3.2 μg/l. Only body mass index (BMI) correlated significantly (p
KW - Differentiated thyroid carcinoma
KW - Leptin
KW - rhTSH
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M3 - Article
C2 - 19092294
AN - SCOPUS:58649086532
VL - 31
SP - 888
EP - 892
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 10
ER -