Absolute and relative activities of platinum-complexes on human tumors as evaluated by an antimetabolic in vitro assay

Maria Grazia Daidone, Rosella Silvestrini, Nadia Zaffaroni, Egle Grignolio, Fabio Landoni

Research output: Contribution to journalArticle

Abstract

An in vitro assay, which evaluates drug effect on 3H-thymidine incorporation, was used to investigate the absolute and relative activities of cisplatin (DDP), carboplatin (CBDCA) and iproplatin (CHIP) on 317 specimens from untreated tumors, including breast and ovarian cancers and malignant melanomas. Similar activities were generally observed for DDP and CHIP, whereas CBDCA exhibited a lower, although not significantly different cytotoxicity on breast and ovarian cancers. The relative activities of Platinum analogues were analyzed on 239 two-way drug sensitivity comparisons. The overall agreement rates ranged from 80.2 to 83.9% for the different comparisons. High coresistance, from 61.1 to 93.8%, was observed for all the comparisons, regardless of the tumor type. Cosensitivity rates were poor for breast and ovarian cancers, from 0 to 37.5%, whereas for melanomas an association in sensitivity was observed in 80% of the cases.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalInvestigational New Drugs
Volume5
Issue number3
DOIs
Publication statusPublished - Sep 1987

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Keywords

  • antimetabolic assay
  • carboplatin
  • cisplatin
  • iproplatin

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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