Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor

M Ferro, G Di Lorenzo, M D Vartolomei, D Bruzzese, F Cantiello, G Lucarelli, G Musi, S Di Stasi, R Hurle, G Guazzoni, G M Busetto, A Gabriele, F Del Giudice, R Damiano, F Perri, S Perdona, P Verze, M Borghesi, R Schiavina, G L AlmeidaP Bove, E Lima, R Autorino, N Crisan, A R Abu Farhan, M Battaglia, G I Russo, Vincenzo Ieluzzi, G Morgia, P De Placido, D Terracciano, A Cimmino, L Scafuri, V Mirone, O De Cobelli, S Shariat, Guru Sonpavde, C Buonerba

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Abstract

BACKGROUND: Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.METHODS: We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. After re-TURBT, patients were treated with a 6-week course of intravesical BCG induction followed by intravesical BCG every week for 3 weeks given at 3, 6, 12, 18, 24, 30 and 36 months from initiation of therapy The analysis of potential risk factors for recurrence, muscle invasion and cancer-specific and overall survival was performed using univariable Cox regression models. Those factors that presented, at univariate analysis, an association with the event at a liberal p 
Original languageEnglish
Pages (from-to)143-150
Number of pages8
JournalWorld Journal of Urology
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2020

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Ferro, M., Di Lorenzo, G., Vartolomei, M. D., Bruzzese, D., Cantiello, F., Lucarelli, G., Musi, G., Di Stasi, S., Hurle, R., Guazzoni, G., Busetto, G. M., Gabriele, A., Del Giudice, F., Damiano, R., Perri, F., Perdona, S., Verze, P., Borghesi, M., Schiavina, R., ... Buonerba, C. (2020). Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor. World Journal of Urology, 38(1), 143-150. https://doi.org/10.1007/s00345-019-02754-2