Absolute neutrophil counts and fibrinogen levels as an aid in the early diagnosis of acute myocardial infarction

Stefania Basili, Manuela Di Franco, Antonello Rosa, Patrizia Ferroni, Veronica Diurni, Maria Gabriella Scarpellini, Giuliano Bertazzoni

Research output: Contribution to journalArticle

Abstract

A retrospective analysis of white blood cell (WBC) counts and fibrinogen levels was performed on 292 consecutive patients admitted to the emergency department for chest pain likely due to ischaemic heart disease. Aims of the study were to evaluate their utility in discriminating between cardiac and non-cardiac chest pain, and to identify those "chest pain-enzyme negative" patients who are at high risk of developing acute myocardial infarction (AMI). The results obtained showed thatWBC (p <0.0001) and fibrinogen (p <0.0001) significantly discriminated AMI patients. However, only male gender (p <0.03), abnormal CK-MB% (p <0.0001) and neutrophil counts (p <0.0001) were independently related to AMI. The combined determination of neutrophils and CK-MB% increased the sensitivity from 50% (for CK-MB% alone) to 70% (p <0.05), with a negative predictive value similar to that observed for CK-MB% alone. These results suggest that determination of neutrophil counts might help to improve the accuracy of AMI diagnosis in emergency patients.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalActa Cardiologica
Volume59
Issue number2
DOIs
Publication statusPublished - Apr 2004

Keywords

  • Acute myocardial infarction
  • Cardiac enzymes
  • Chest pain
  • Fibrinogen
  • Neutrophils

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Absolute neutrophil counts and fibrinogen levels as an aid in the early diagnosis of acute myocardial infarction'. Together they form a unique fingerprint.

Cite this