Absolute quantitation of short te brain1h-mr spectra and spectroscopic imaging data

Jeffry R. Alger, Sophia C. Symko, Alberto Bizzi, Stefan Posse, Daryl J. Despres, Mark R. Armstrong

Research output: Contribution to journalArticle


A method for determining the concentrations of the materials that produce the well-resolved singlet signals in short TE brain ‘H MR spectroscopic examinations is presented. Concentration determination is achieved by a water-referencing procedure. The ratios of the areas of the choline, total creatine, and N-acetyl signals to that of the water signal from the same volume of interest (VOI) are determined using acquisitions with and without water suppression. The tissue concentrations of the molecules producing the three signals can then be determined if the water concentration in the VOI can be found. This is done with a density-weighted MR study. The MR study provides the ratio of the mean MR signal amplitude from the VOI to that from an external standard containing a known water concentration. The method’s flexibility is illustrated by using it with two different single-volume localization schemes and spectroscopic imaging. Preliminary evaluations of accuracy and reproducibility are made in phantom, animal, and limited human studies. The method’s advantages and limitations are discussed.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalJournal of Computer Assisted Tomography
Issue number2
Publication statusPublished - 1993


  • Brain
  • Magnetic resonance imaging techniques
  • Magnetic resonance spectroscopy (MRS)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Alger, J. R., Symko, S. C., Bizzi, A., Posse, S., Despres, D. J., & Armstrong, M. R. (1993). Absolute quantitation of short te brain1h-mr spectra and spectroscopic imaging data. Journal of Computer Assisted Tomography, 17(2), 191-199.