Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect?

Alessia Pascale, Cecilia Osera, Federico Moro, Angelo Di Clemente, Giuseppe Giannotti, Lucia Caffino, Stefano Govoni, Fabio Fumagalli, Luigi Cervo

Research output: Contribution to journalArticle

Abstract

We previously demonstrated that nELAV/GAP-43 pathway is pivotal for learning and its hippocampal expression is up-regulated by acute stress following repeated cocaine administration. We therefore hypothesized that abstinence-induced stress may sustain nELAV/GAP-43 pathway during early abstinence following 2 weeks of cocaine self-administration. We found that contingent, but not non-contingent, cocaine exposure selectively increases hippocampal nELAV, but not GAP-43, expression immediately after the last self-administration session, an effect that wanes after 24 h and that comes back 7 days later when nELAV activation becomes associated with increased expression of GAP-43, an effect again observed only in animals self-administering the psychostimulant. Such effect is specific for nELAV since the ubiquitous ELAV/HuR is unchanged. This nELAV profile suggests that its initial transient alteration is perhaps related to the daily administration of cocaine, while the increase in the nELAV/GAP-43 pathway following a week of abstinence may reflect the activation of this cascade as a target of stressful conditions associated with drug-related memories.

Original languageEnglish
Pages (from-to)700-704
JournalHippocampus
Volume26
DOIs
Publication statusPublished - 2016

Keywords

  • Cocaine
  • GAP-43
  • Hippocampus
  • NELAV
  • Self-administration

ASJC Scopus subject areas

  • Cognitive Neuroscience

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    Pascale, A., Osera, C., Moro, F., Di Clemente, A., Giannotti, G., Caffino, L., Govoni, S., Fumagalli, F., & Cervo, L. (2016). Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect? Hippocampus, 26, 700-704. https://doi.org/10.1002/hipo.22572