Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect?

Alessia Pascale, Cecilia Osera, Federico Moro, Angelo Di Clemente, Giuseppe Giannotti, Lucia Caffino, Stefano Govoni, Fabio Fumagalli, Luigi Cervo

Research output: Contribution to journalArticle

Abstract

We previously demonstrated that nELAV/GAP-43 pathway is pivotal for learning and its hippocampal expression is up-regulated by acute stress following repeated cocaine administration. We therefore hypothesized that abstinence-induced stress may sustain nELAV/GAP-43 pathway during early abstinence following 2 weeks of cocaine self-administration. We found that contingent, but not non-contingent, cocaine exposure selectively increases hippocampal nELAV, but not GAP-43, expression immediately after the last self-administration session, an effect that wanes after 24 h and that comes back 7 days later when nELAV activation becomes associated with increased expression of GAP-43, an effect again observed only in animals self-administering the psychostimulant. Such effect is specific for nELAV since the ubiquitous ELAV/HuR is unchanged. This nELAV profile suggests that its initial transient alteration is perhaps related to the daily administration of cocaine, while the increase in the nELAV/GAP-43 pathway following a week of abstinence may reflect the activation of this cascade as a target of stressful conditions associated with drug-related memories.

Original languageEnglish
Pages (from-to)700-704
JournalHippocampus
Volume26
DOIs
Publication statusPublished - 2016

Fingerprint

GAP-43 Protein
Self Administration
Cocaine
Hippocampus
Learning
Pharmaceutical Preparations

Keywords

  • Cocaine
  • GAP-43
  • Hippocampus
  • NELAV
  • Self-administration

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus : A stress-related effect? / Pascale, Alessia; Osera, Cecilia; Moro, Federico; Di Clemente, Angelo; Giannotti, Giuseppe; Caffino, Lucia; Govoni, Stefano; Fumagalli, Fabio; Cervo, Luigi.

In: Hippocampus, Vol. 26, 2016, p. 700-704.

Research output: Contribution to journalArticle

Pascale, A, Osera, C, Moro, F, Di Clemente, A, Giannotti, G, Caffino, L, Govoni, S, Fumagalli, F & Cervo, L 2016, 'Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect?', Hippocampus, vol. 26, pp. 700-704. https://doi.org/10.1002/hipo.22572
Pascale, Alessia ; Osera, Cecilia ; Moro, Federico ; Di Clemente, Angelo ; Giannotti, Giuseppe ; Caffino, Lucia ; Govoni, Stefano ; Fumagalli, Fabio ; Cervo, Luigi. / Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus : A stress-related effect?. In: Hippocampus. 2016 ; Vol. 26. pp. 700-704.
@article{7847f4d1ec5f494f8855aae14d97216b,
title = "Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect?",
abstract = "We previously demonstrated that nELAV/GAP-43 pathway is pivotal for learning and its hippocampal expression is up-regulated by acute stress following repeated cocaine administration. We therefore hypothesized that abstinence-induced stress may sustain nELAV/GAP-43 pathway during early abstinence following 2 weeks of cocaine self-administration. We found that contingent, but not non-contingent, cocaine exposure selectively increases hippocampal nELAV, but not GAP-43, expression immediately after the last self-administration session, an effect that wanes after 24 h and that comes back 7 days later when nELAV activation becomes associated with increased expression of GAP-43, an effect again observed only in animals self-administering the psychostimulant. Such effect is specific for nELAV since the ubiquitous ELAV/HuR is unchanged. This nELAV profile suggests that its initial transient alteration is perhaps related to the daily administration of cocaine, while the increase in the nELAV/GAP-43 pathway following a week of abstinence may reflect the activation of this cascade as a target of stressful conditions associated with drug-related memories.",
keywords = "Cocaine, GAP-43, Hippocampus, NELAV, Self-administration",
author = "Alessia Pascale and Cecilia Osera and Federico Moro and {Di Clemente}, Angelo and Giuseppe Giannotti and Lucia Caffino and Stefano Govoni and Fabio Fumagalli and Luigi Cervo",
year = "2016",
doi = "10.1002/hipo.22572",
language = "English",
volume = "26",
pages = "700--704",
journal = "Hippocampus",
issn = "1050-9631",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus

T2 - A stress-related effect?

AU - Pascale, Alessia

AU - Osera, Cecilia

AU - Moro, Federico

AU - Di Clemente, Angelo

AU - Giannotti, Giuseppe

AU - Caffino, Lucia

AU - Govoni, Stefano

AU - Fumagalli, Fabio

AU - Cervo, Luigi

PY - 2016

Y1 - 2016

N2 - We previously demonstrated that nELAV/GAP-43 pathway is pivotal for learning and its hippocampal expression is up-regulated by acute stress following repeated cocaine administration. We therefore hypothesized that abstinence-induced stress may sustain nELAV/GAP-43 pathway during early abstinence following 2 weeks of cocaine self-administration. We found that contingent, but not non-contingent, cocaine exposure selectively increases hippocampal nELAV, but not GAP-43, expression immediately after the last self-administration session, an effect that wanes after 24 h and that comes back 7 days later when nELAV activation becomes associated with increased expression of GAP-43, an effect again observed only in animals self-administering the psychostimulant. Such effect is specific for nELAV since the ubiquitous ELAV/HuR is unchanged. This nELAV profile suggests that its initial transient alteration is perhaps related to the daily administration of cocaine, while the increase in the nELAV/GAP-43 pathway following a week of abstinence may reflect the activation of this cascade as a target of stressful conditions associated with drug-related memories.

AB - We previously demonstrated that nELAV/GAP-43 pathway is pivotal for learning and its hippocampal expression is up-regulated by acute stress following repeated cocaine administration. We therefore hypothesized that abstinence-induced stress may sustain nELAV/GAP-43 pathway during early abstinence following 2 weeks of cocaine self-administration. We found that contingent, but not non-contingent, cocaine exposure selectively increases hippocampal nELAV, but not GAP-43, expression immediately after the last self-administration session, an effect that wanes after 24 h and that comes back 7 days later when nELAV activation becomes associated with increased expression of GAP-43, an effect again observed only in animals self-administering the psychostimulant. Such effect is specific for nELAV since the ubiquitous ELAV/HuR is unchanged. This nELAV profile suggests that its initial transient alteration is perhaps related to the daily administration of cocaine, while the increase in the nELAV/GAP-43 pathway following a week of abstinence may reflect the activation of this cascade as a target of stressful conditions associated with drug-related memories.

KW - Cocaine

KW - GAP-43

KW - Hippocampus

KW - NELAV

KW - Self-administration

UR - http://www.scopus.com/inward/record.url?scp=84959421858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959421858&partnerID=8YFLogxK

U2 - 10.1002/hipo.22572

DO - 10.1002/hipo.22572

M3 - Article

AN - SCOPUS:84959421858

VL - 26

SP - 700

EP - 704

JO - Hippocampus

JF - Hippocampus

SN - 1050-9631

ER -