Acanthamoeba castellanii promotion of in vitro survival and transmission of coxsackie B3 viruses

A. Mattana, C. Serra, E. Mariotti, G. Delogu, P. L. Fiori, P. Cappuccinelli

Research output: Contribution to journalArticle

Abstract

This work was undertaken to determine whether Acanthamoeba could play a role in the survival and transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and their transmission to human hosts.

Original languageEnglish
Pages (from-to)665-671
Number of pages7
JournalEukaryotic Cell
Volume5
Issue number4
DOIs
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Microbiology

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    Mattana, A., Serra, C., Mariotti, E., Delogu, G., Fiori, P. L., & Cappuccinelli, P. (2006). Acanthamoeba castellanii promotion of in vitro survival and transmission of coxsackie B3 viruses. Eukaryotic Cell, 5(4), 665-671. https://doi.org/10.1128/EC.5.4.665-671.2006