Abstract
Background: Episodic non-ketotic hyperglycaemia in patients with diabetes may be responsible for a syndrome characterised by hemichorea-hemiballism associated with unique radiological features. Objective: To investigate whether factors other than hyperglycaemia may be responsible for the neurological involvement. Methods: Three patients who developed a persistent choreaballism syndrome triggered by a hyperglycaemic crisis were investigated. In these patients, the persistence of the involuntary movements required neuroleptic medication. Results: T1 weighted magnetic resonance imaging revealed bilateral hyperintense lesions involving the striatum. Surprisingly, in these patients, the laboratory investigations revealed peripheral red blood cell acanthocytosis in a significant proportion of cells. Conclusion: Compared with the large population of patients with diabetes who do not show abnormal involuntary movements, unrecognised acanthocytosis in diabetes might render patients prone to develop hemichorea-hemiballism.
| Original language | English |
|---|---|
| Pages (from-to) | 1717-1719 |
| Number of pages | 3 |
| Journal | Journal of Neurology, Neurosurgery and Psychiatry |
| Volume | 76 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
- Psychiatry and Mental health
Cite this
Acanthocytosis as a predisposing factor for non-ketotic hyperglycaemia induced chorea-ballism. / Pisani, A.; Diomedi, M.; Rum, A.; Cianciulli, P.; Floris, R.; Orlacchio, A.; Bernardi, G.; Calabresi, P.
In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 76, No. 12, 12.2005, p. 1717-1719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acanthocytosis as a predisposing factor for non-ketotic hyperglycaemia induced chorea-ballism
AU - Pisani, A.
AU - Diomedi, M.
AU - Rum, A.
AU - Cianciulli, P.
AU - Floris, R.
AU - Orlacchio, A.
AU - Bernardi, G.
AU - Calabresi, P.
PY - 2005/12
Y1 - 2005/12
N2 - Background: Episodic non-ketotic hyperglycaemia in patients with diabetes may be responsible for a syndrome characterised by hemichorea-hemiballism associated with unique radiological features. Objective: To investigate whether factors other than hyperglycaemia may be responsible for the neurological involvement. Methods: Three patients who developed a persistent choreaballism syndrome triggered by a hyperglycaemic crisis were investigated. In these patients, the persistence of the involuntary movements required neuroleptic medication. Results: T1 weighted magnetic resonance imaging revealed bilateral hyperintense lesions involving the striatum. Surprisingly, in these patients, the laboratory investigations revealed peripheral red blood cell acanthocytosis in a significant proportion of cells. Conclusion: Compared with the large population of patients with diabetes who do not show abnormal involuntary movements, unrecognised acanthocytosis in diabetes might render patients prone to develop hemichorea-hemiballism.
AB - Background: Episodic non-ketotic hyperglycaemia in patients with diabetes may be responsible for a syndrome characterised by hemichorea-hemiballism associated with unique radiological features. Objective: To investigate whether factors other than hyperglycaemia may be responsible for the neurological involvement. Methods: Three patients who developed a persistent choreaballism syndrome triggered by a hyperglycaemic crisis were investigated. In these patients, the persistence of the involuntary movements required neuroleptic medication. Results: T1 weighted magnetic resonance imaging revealed bilateral hyperintense lesions involving the striatum. Surprisingly, in these patients, the laboratory investigations revealed peripheral red blood cell acanthocytosis in a significant proportion of cells. Conclusion: Compared with the large population of patients with diabetes who do not show abnormal involuntary movements, unrecognised acanthocytosis in diabetes might render patients prone to develop hemichorea-hemiballism.
UR - http://www.scopus.com/inward/record.url?scp=28144463483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28144463483&partnerID=8YFLogxK
U2 - 10.1136/jnnp.2005.067033
DO - 10.1136/jnnp.2005.067033
M3 - Article
VL - 76
SP - 1717
EP - 1719
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 12
ER -