ACC/AHA/HRS Versus ESC Guidelines for the Diagnosis and Management of Syncope: JACC Guideline Comparison

Zachary D. Goldberger, Bradley J. Petek, Michele Brignole, Win Kuang Shen, Robert S. Sheldon, Monica Solbiati, Jean Claude Deharo, Angel Moya, Mohamed H. Hamdan

Research output: Contribution to journalReview articlepeer-review


Syncope is a commonly encountered and challenging problem in medical practice. Presentations are variable, and the causal mechanism often remains elusive even after extensive (and often expensive) evaluation. Clinical practice guidelines have been developed to help guide the multidisciplinary approach necessary to diagnose and manage the broad spectrum of patients presenting with syncope. The American College of Cardiology/American Heart Association, in collaboration with the Heart Rhythm Society, published its first syncope guidelines in 2017. The European Society of Cardiology released the fourth iteration of its syncope guidelines in 2018. This review highlights the differences and congruencies between the 2 sets of recommendations, their implications for clinical practice, the remaining gaps in understanding, and areas of future research.

Original languageEnglish
Pages (from-to)2410-2423
Number of pages14
JournalJournal of the American College of Cardiology
Issue number19
Publication statusPublished - Nov 12 2019


  • bifascicular block
  • clinical practice guidelines
  • electrophysiological study
  • implantable loop recorder
  • orthostatic hypotension
  • permanent pacemaker
  • reflex syncope
  • syncope

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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