Accelerated catabolism of hydrocortisone in isolated perfused liver of tumor-bearing rats

Ivan Bartošek, Viviana Marc, Amalia Guaitani, Silvio Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

The rate of hydrocortisone disappearance from the medium was followed during the perfusion of livers isolated from normal and Walker 256 tumor-bearing rats. The half-life of hydrocortisone found during the perfusions of tumor livers with tumor blood was only about half (12.8 min) of that found during perfusions of normal livers with normal blood (22.4 min). The cross experiments, normal livers perfused with tumor blood and vice versa, demonstrated that blood does not influence the rate of hydrocortisone disappearance, which is determined exclusively by the state of liver tissue.

Original languageEnglish
Pages (from-to)2429-2431
Number of pages3
JournalBiochemical Pharmacology
Volume22
Issue number19
DOIs
Publication statusPublished - Oct 1 1973

ASJC Scopus subject areas

  • Pharmacology

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