We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.
|Number of pages||3|
|Journal||Allergy: European Journal of Allergy and Clinical Immunology|
|Publication status||Published - 1996|
- broncho-obstructive reaction
- delayed hypersensitivity
ASJC Scopus subject areas