Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report

A. Romano, M. Di Fonso, F. Mormile, D. Quaratino, F. Giuffreda, A. Venuti

Research output: Contribution to journalArticlepeer-review


We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number4
Publication statusPublished - 1996


  • broncho-obstructive reaction
  • delayed hypersensitivity
  • stepronin

ASJC Scopus subject areas

  • Immunology


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