Accelerated epigenetic aging in Down syndrome

Steve Horvath, Paolo Garagnani, Maria Giulia Bacalini, Chiara Pirazzini, Stefano Salvioli, Davide Gentilini, Anna Maria Di Blasio, Cristina Giuliani, Spencer Tung, Harry V. Vinters, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10-14).

Original languageEnglish
Pages (from-to)491-495
Number of pages5
JournalAging Cell
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Biomarker of aging
  • DNA methylation
  • Down syndrome
  • Epigenetics

ASJC Scopus subject areas

  • Cell Biology
  • Ageing

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    Horvath, S., Garagnani, P., Bacalini, M. G., Pirazzini, C., Salvioli, S., Gentilini, D., Di Blasio, A. M., Giuliani, C., Tung, S., Vinters, H. V., & Franceschi, C. (2015). Accelerated epigenetic aging in Down syndrome. Aging Cell, 14(3), 491-495. https://doi.org/10.1111/acel.12325