Accelerated epigenetic aging in Down syndrome

Steve Horvath, Paolo Garagnani, Maria Giulia Bacalini, Chiara Pirazzini, Stefano Salvioli, Davide Gentilini, Anna Maria Di Blasio, Cristina Giuliani, Spencer Tung, Harry V. Vinters, Claudio Franceschi

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10-14).

Original languageEnglish
Pages (from-to)491-495
Number of pages5
JournalAging Cell
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Down Syndrome
Epigenomics
Chronic Disease
Brain

Keywords

  • Biomarker of aging
  • DNA methylation
  • Down syndrome
  • Epigenetics

ASJC Scopus subject areas

  • Cell Biology
  • Ageing

Cite this

Horvath, S., Garagnani, P., Bacalini, M. G., Pirazzini, C., Salvioli, S., Gentilini, D., ... Franceschi, C. (2015). Accelerated epigenetic aging in Down syndrome. Aging Cell, 14(3), 491-495. https://doi.org/10.1111/acel.12325

Accelerated epigenetic aging in Down syndrome. / Horvath, Steve; Garagnani, Paolo; Bacalini, Maria Giulia; Pirazzini, Chiara; Salvioli, Stefano; Gentilini, Davide; Di Blasio, Anna Maria; Giuliani, Cristina; Tung, Spencer; Vinters, Harry V.; Franceschi, Claudio.

In: Aging Cell, Vol. 14, No. 3, 01.06.2015, p. 491-495.

Research output: Contribution to journalArticle

Horvath, S, Garagnani, P, Bacalini, MG, Pirazzini, C, Salvioli, S, Gentilini, D, Di Blasio, AM, Giuliani, C, Tung, S, Vinters, HV & Franceschi, C 2015, 'Accelerated epigenetic aging in Down syndrome', Aging Cell, vol. 14, no. 3, pp. 491-495. https://doi.org/10.1111/acel.12325
Horvath S, Garagnani P, Bacalini MG, Pirazzini C, Salvioli S, Gentilini D et al. Accelerated epigenetic aging in Down syndrome. Aging Cell. 2015 Jun 1;14(3):491-495. https://doi.org/10.1111/acel.12325
Horvath, Steve ; Garagnani, Paolo ; Bacalini, Maria Giulia ; Pirazzini, Chiara ; Salvioli, Stefano ; Gentilini, Davide ; Di Blasio, Anna Maria ; Giuliani, Cristina ; Tung, Spencer ; Vinters, Harry V. ; Franceschi, Claudio. / Accelerated epigenetic aging in Down syndrome. In: Aging Cell. 2015 ; Vol. 14, No. 3. pp. 491-495.
@article{ee2b9c839edd4e779ff2f281937f7c52,
title = "Accelerated epigenetic aging in Down syndrome",
abstract = "Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10-14).",
keywords = "Biomarker of aging, DNA methylation, Down syndrome, Epigenetics",
author = "Steve Horvath and Paolo Garagnani and Bacalini, {Maria Giulia} and Chiara Pirazzini and Stefano Salvioli and Davide Gentilini and {Di Blasio}, {Anna Maria} and Cristina Giuliani and Spencer Tung and Vinters, {Harry V.} and Claudio Franceschi",
year = "2015",
month = "6",
day = "1",
doi = "10.1111/acel.12325",
language = "English",
volume = "14",
pages = "491--495",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Accelerated epigenetic aging in Down syndrome

AU - Horvath, Steve

AU - Garagnani, Paolo

AU - Bacalini, Maria Giulia

AU - Pirazzini, Chiara

AU - Salvioli, Stefano

AU - Gentilini, Davide

AU - Di Blasio, Anna Maria

AU - Giuliani, Cristina

AU - Tung, Spencer

AU - Vinters, Harry V.

AU - Franceschi, Claudio

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10-14).

AB - Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10-14).

KW - Biomarker of aging

KW - DNA methylation

KW - Down syndrome

KW - Epigenetics

UR - http://www.scopus.com/inward/record.url?scp=84927909490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927909490&partnerID=8YFLogxK

U2 - 10.1111/acel.12325

DO - 10.1111/acel.12325

M3 - Article

AN - SCOPUS:84927909490

VL - 14

SP - 491

EP - 495

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 3

ER -