Accelerated fractionation in advanced head and neck cancer: results and analysis of late sequelae

Patrizia Olmi, Enrico Cellai, Andrea Chiavacci, Carlo Fallai

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From 1975 to 1985, 161 patients affected by head and neck cancer (58 oropharynx, 67 oral cavity, 36 paranasal sinuses) were treated with radiotherapy using an accelerated fractionation (AF) schedule at the University and Hospital Radiotherapy Departments of Florence. Most cases, classified with U.I.C.C. and A.J.C. TNM 1978 were advanced ( 137 161 = 85%). Five-year actuarial local control and survival was 38% for the oropharynx, 18% and 20% for the oral cavity, and 38% and 31% for the paranasal sinuses. Results were analysed according to T and N stage as well. Severe late sequelae were evaluated in 53 patients without local disease and with a minimum follow-up of one year: 8 patients developed osteonecrosis; there were 3 cases of trismus, 2 cases of laryngeal oedema, one case of blindness and one case of ophthalmitis.

Original languageEnglish
Pages (from-to)199-207
Number of pages9
JournalRadiotherapy and Oncology
Issue number3
Publication statusPublished - 1990



  • Accelerated fractionation
  • Head
  • neck cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Urology

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