Accelerated hypo-fractionation by biological equivalent DVH for patients affected by gastric carcinoma in postoperative concomitant radiochemotherapy

P. Pedicini, M. Mazziotta, S. Clemente, M. Cozzolino, L. Caporaso, P. Sanpaolo, V. Barbieri, L. Lapadula, G. Castaldo, V. Fusco

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent result of clinical trial on carcinoma of stomach demonstrate an advantage to adjuvant postoperative chemo-radiotherapy witch is now used more commonly for gastric cancer. However remain some doubt for toxicity as for the optimal chemotherapy regimen as for the optimal method of radiation delivery. To increase the biological effectiveness and, at same time, to reduce toxicity of conventional radiotherapy we tested many alternative fractionation schemes of dose radiation, using a biological equivalent Histogram Dose Volume (DVH) for prior analysis and as tool for the assessment and choice of fractionation dose biologically more effective.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages223-226
Number of pages4
Volume25
Edition3
DOIs
Publication statusPublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Radiation Protection and Dosimetry, Biological Effects of Radiation - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Radiation Protection and Dosimetry, Biological Effects of Radiation
CountryGermany
CityMunich
Period9/7/099/12/09

Keywords

  • Biological equivalent dose
  • Chemo-radiotherapy
  • Dose volume histogram
  • Fractionation
  • Tolerance dose

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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